Chronic copper toxicity was diagnosed in a Jersey herd in the Waikato region of New Zealand following an investigation into the deaths of six cattle from a herd of 250 dry cows. Clinical signs and post-mortem examination results were consistent with a hepatopathy, and high concentrations of copper in liver and blood samples of clinically affected animals confirmed copper toxicity. Liver copper ...

BACKGROUND/AIMS The pathogenesis of non-alcoholic steatohepatitis (NASH) is poorly understood. Hepatic iron and copper overload can directly cause lipid peroxidation and eventually hepatic damage. The aim of this study was to investigate the role of hepatic iron and copper accumulation in the development of NASH. METHODS Fifty-three patients with NASH were studied. All patients underwent live...

OBJECTIVE This study was designed to compare the effect of Helicobacter pylori (H. pylori) infection treatment on serum zinc, copper, and selenium levels. PATIENTS AND METHODS We measured the serum zinc, copper, and selenium levels in H. pylori-positive and H. pylori-negative patients. We also evaluated the serum levels of these trace elements after H. pylori eradication. These serum copper, ...

BACKGROUND Wilson's disease (WD) is an inherited disorder of copper metabolism leading to liver failure and/or neurological impairment. Its diagnosis often remains difficult even with genetic testing. Relative exchangeable copper (REC) has recently been described as a reliable serum diagnostic marker for WD. METHODOLOGY/PRINCIPAL FINDINGS The aim of this study was to validate the use of REC i...

Background: Soil and plant contamination in copper exposure causes chronic copper poisoning (CCP) in animals following the consumption of plants in these soils. Objectives: The present study was carried out on 10 clinically affected copper poisoned cases (in each season) from autumn 2015 to the end of summer 2016, in four seasons in Kerman province to evaluate the seasonal effects of CCP in she...

Background and Aims: Giardia lamblia infection is a common cause of food and water-borne diarrhea in non-sanitary communities. Infections are common in children, particularly in child-care centers, backpackers, travelers, and homosexuals. Zinc is necessary for the immune system functions. Zinc deficiency is associated with acute diarrhea. Copper is essential for the production of red blood cell...

LIFSCHITZ, M. D., AND R. I. HENKIN. Circadian variation in copper and zinc in man. J. Appl. Physiol. 31(l): 88-92. 1971.~Copper and zinc metabolism were studied in 10 normal volunteers on a constant regimen consisting of an alternate 4 hourly intake of a liquid diet or distilled water, and a regulated amount of activity. Urine was collected in 4-hr periods and blood samples drawn in the middle ...

This study was to determine the feasibility of using potentiometric stripping analysis (PSA) to measure serum levels of copper, lead, and zinc in elderly subjects with metabolic disorders (hyperglycemia, hypertriglyceridemia, and hypercholesterolemia). Furthermore, we investigated the relationship between serum trace elements and lipid and glucose levels in these patients. There was a strong co...

The involvement of elements in the pathological process of primary hypertension has been established. The serum levels of copper, iron, zinc, sodium, potassium and calcium were studied by atomic absorption spectrophotometery and flame photometry in hypertensive and normal subjects. Serum copper and zinc levels were increased in hypertensive patients (25.5% and 14.7% respectively) as compar...