objective(s):to evaluate the effect of trinitroglycerin (tng) as nitric oxide donor agent on serum copper (cu) and zinc (zn) levels and liver enzymes in balb/c mice infected with leishmania major (l. major) mrho/ir/75/er. materials and methods: inbred female mice were divided into three groups: healthy group (uninfected naive mice), control group (infected with l. major), and test group (l. maj...

Lysosomal disruption with release of lysosomal enzymes has been described in shock. Our study was designed to demonstrate the release of lysosomal enzymes in the liver and lung in addition to determining circulating serum lysosomal enzyme values. Terapeutic means of reducing or inhibiting lysosomal disruption were also investigated. Five groups of baboons were investigated: Group A: (control gr...

Background: Diets rich in simple carbohydrates can induce obesity and metabolic syndrome. Objectives: In this study we investigated the effect of aqueous extract of Inocutis levis on the levels of serum lipids and liver tissue in high sucrose fed (HSF) rats. Methods: Thirty two male wistar rats were divided into 4 groups: 1- control, 2- a group that were fed with high sucrose solution for 12...

introduction: this study was performed to establish a complementary method to the diagnosis of complete hydatidiform mole and its differentiation from the other cases of gestational trophoblastic disease by measuring the total (alp) and placental alkaline phosphatase (plap) specific activity. materials and methods: serum and tissue extracts from 13 patients, 13 normal non-pregnant and 30 pregna...

Purpose: To investigate the effect of quaternary amines on myocardial cells a rat model cardiac arrest, with respect to energy generation potential and oxygen free radicals.
 Methods: Forty-five Sprague-Dawley (SD) rats were assigned sham, amine groups (each 15 rats). After their corresponding treatments, lectrocardiogram (ECG) monitoring in three at various time periods was carried out. S...

the present study investigated the effects of e. coli lipopolysaccharide (lps) induced mastitis model in rat on the activity of antioxidant enzyme systems. to achieve this purpose, e. coli lps were infused into the mammary gland of 12 rats 72 hr postpartum and compared with 12 rats in control group infused intramammary placebo sterile pyrogene – free, physiological saline. the antioxidant activ...

In order to investigate the effects of peppermint (Mentha piperita L.) alcoholic extract on liver injury caused by the oxidant carbon tetrachloride (CCl4), an experiment was performed as a completely randomized design in a factorial arrangement (2 × 2) with 4 replications of 10 broilers each. Factors included two levels of peppermint leaf alcoholic extract (0 and 2 mL/Kg body weight) and CCl4 (...

Introduction: One of the main mechanisms by which diabetic complications occur is an alteration of the structure and function of proteins due to hyperglycemia. Aspirin (ASA) affects cellular pathways through different mechanisms, including glycation inhibition and antioxidant activity. The aim of the present study, as a follow up to our previous one, is to investigate the effect of long-term, h...