نتایج جستجو برای: serum starvation
تعداد نتایج: 317180 فیلتر نتایج به سال:
[Purpose] Cast immobilization- and cell starvation-induced loss of muscle mass are closely associated with a dramatic reduction in the structural muscle proteins. Heat shock proteins are molecular chaperones that are constitutively expressed in several eukaryotic cells and have been shown to protect against various stressors. However, the changes in the phosphorylation of atrophy-related heat s...
calcium-binding proteins play essential roles in the cell. one important class of calcium-binding proteins is the annexin family. this is a family of 13 proteins, which binds to phospholipids in a calcium-dependent manner. osteosarcoma cell line (mg-63) is a transformed cell that has many characteristics of the differentiated cell, such as a considerable serum dependency in its growth rate. usi...
Naked mole-rats (NMR; Heterocephalus glaber) display extreme longevity and resistance to cancer. Here, we examined whether autophagy contributes to the longevity of NMRs by assessing the effects of the PI3K/Akt pathway inhibitor LY294002 and the autophagy inhibitor chloroquine (CQ) on autophagy and apoptosis in NMR skin fibroblasts. Serum starvation, H2O2 treatment, and LY294002 treatment all i...
BACKGROUND The transcription factor forkhead box D3 (FOXD3) plays important roles in the development of neural crest and has been shown to suppress the development of various cancers. However, the expression and its potential biological roles of FOXD3 in high-grade gliomas (HGGs) remain unknown. METHODS The mRNA and protein expression levels of FOXD3 were examined using real-time quantitative...
SREBPs (sterol-regulatory-element-binding proteins) are a family of transcription factors that modulate the expression of several enzymes implicated in endogenous cholesterol, fatty acid, triacylglycerol and phospholipid synthesis. In the present study, evidence for SREBP-1 regulation at the translational level is reported. Using several experimental approaches, we have demonstrated that the 5'...
BACKGROUND Loss of muscle protein is a common feature of wasting diseases where currently treatment is limited. This study investigates the potential of epigallocatechin-3-gallate (EGCg), the most abundant catechin in green tea, to reverse the increased protein degradation and rescue the decreased protein synthesis which leads to muscle atrophy. METHODS Studies were conducted in vitro using m...
In this study, the effects of starvation and re-feeding on growth performance and body biochemical composition of Blue Streak Hap (Labidochromis caeruleus) were conducted at autumn 2014. A total of 450 fish were assigned to 5 treatments with 3 replicates. 15 tanks were prepared with a volume of approximately 120 liters and trial period was considered 48 days in experimental conditions. Treatmen...
The mechanisms of the increased serum leptin in response to feeding are poorly understood. Therefore, we used metabolic labeling to directly assess leptin biosynthesis, secretion, and turnover in adipose tissue from 14 h-starved compared with fed 12-14 week old rats. Starvation decreased serum leptin (-47 +/- 7%), adipose tissue leptin content (-32 +/- 5%), and leptin secretion during 3 h of in...
This study was carried out to investigate the effects of starvation and feeding regimes on growth performance, haematological and biochemical parameters of blood and body composition of Caspian brown trout parr. For this purpose, 900 fish (average weight: 12.5±1 g) were stocked in 300-l tanks (18 tanks at a stocking rate of 50 fish in each tank) using an open system. Six experimental groups com...
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