This paper describes shape analysis of the caudate nucleus structure in a large schizophrenia study (30 controls, 60 schizophrenics). Although analysis of the caudate has not drawn the same attention as the hippocampus, it is a key basal ganglia structure shown to present differences in early development (e.g. autism) and also to present changes due to drug treatment. Left and right caudate wer...

OBJECTIVE The use of the levels of hemoglobin A1c for the monitoring of glycemic control in patients with diabetes mellitus (DM) is an accepted method of clinical usefulness. A study was performed to assess the relative costs of hemoglobin A1c determination by diagnostic testing at or near the site of patient care (point-of-care testing, POCT) and using the standard hemoglobin A1c analyzer. MET...

Of 113 lactobacilli isolated from radurized (5 kGy) minced meat, 7 Lactobacillus sake strains, 1 L. curvatus strain, and 1 L. farciminis strain were used for radiation resistance studies in a semisynthetic substrate (i.e., modified MRS broth). Five reference Lactobacillus spp., one Staphylococcus aureus strain, and one Salmonella typhimurium strain were used for comparative purposes. All L. sak...

Posttranscriptional mechanisms are important for regulation of cellular and viral gene expression. The presence of the 5' cap structure m(7)G(5')ppp(5')Nm is a general feature of mRNAs that provides protection from exoribonuclease digestion and enhances translation. Vaccinia virus and other poxviruses encode enzymes for both cap synthesis and decapping. Decapping is mediated by two related enzy...

The immune and inflammatory responses are largely inhibited by glucocorticosteroids. In thymocytes, for example, glucocorticosteroids cause apoptosis, whereas they suppress the activity of phospholipase A2 and the production of eicosanoids in tissues actively engaged in inflammation. The immunosuppressive action of dexamethasone (DEX) was studied in vitro by employing a model cell system, namel...

To study whether changes in the structure of a T cell receptor (TCR) at a single peptide-contacting residue could affect T cell priming with antigenic peptide, we made transgenic mice with a point mutation in the TCR alpha chain of the D10.G4.1 (D10) TCR and bred them to D10 beta chain transgenic mice. The mutation consisted of a leucine to serine substitution at position 51 (L51S), which we ha...