We undertake the investigation of sheared polymer chains grafted onto flat surfaces to model liposomes covered with polyethylene glycol brushes as a case study for the mechanisms of efficient drug delivery in biologically relevant situations, for example, as carriers for topical treatments of illnesses in the human vasculature. For these applications, specific rheological properties are require...

Endothelial cells play remarkable roles in regulating vascular function in health and disease. Meanwhile, shear stress, which is created due to the friction of the flowing blood on the endothelium of the arterial wall, is critical for vascular homeostasis. Here, the shear stress patterns and its effect on gene expression and vascular function are reviewed.

Granular media are prevalent in dynamic frictional processes throughout nature and technology, from earthquakes to grain transport. Empirical relations describing macroscopic friction as a function of the inertial number have proven successful in predicting experimentally observed velocity and stress profi les when combined with continuum models. However, these relations and the continuum model...

In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: a b s t r a c t a r t i c l e i n f o Keywords: Rock–analog materials Co-seismic slip rates Rate weakening and strengthening...

the influence of lime on the shear strength of soil has been known for centuries. the conventional method to increase the lime content of a soil is to add less than 10% hydrated lime in the form of powder or grout to the soil. this method is convenient for soils to be used as fill material in projects such as road construction, land fill pavements or lime pile; but is not applicable where a lar...

We investigate the rheology of granular materials via molecular dynamics simulations of homogeneous, simple shear flows of soft, frictional, noncohesive spheres. In agreement with previous results for frictionless particles, we observe three flow regimes existing in different domains of particle volume fraction and shear rate, with all stress data collapsing upon scaling by powers of the distan...

Using molecular dynamics simulations, we study the lubricating properties of neutral and charged bottle-brush coatings as a function of the compression and shear stresses and brush grafting density. Our simulations have shown that in charged bottle-brush systems under shear there is a layer with excess counterions located in the middle between brush-bearing surfaces. The main deformation mode o...

To model cohesionless granular flow using continuum theory, the usual approach is to assume the cohesionless Coulomb-Mohr yield condition. However, this yield condition assumes that the angle of internal friction is constant, when according to experimental evidence for most powders the angle of internal friction is not constant along the yield locus, but decreases for decreasing normal stress c...

[1] A central problem in studies of fault interaction and earthquake triggering is that of quantifying changes in frictional strength and the constitutive response caused by dynamic stressing. We imposed normal stress vibrations on creeping laboratory shear zones to investigate the process of dynamic weakening and the conditions under which resonant frictional behavior occurs. Layers of quartz ...

In the present work, it is shown that the friction stress of ethylene glycol can decrease by an order of magnitude to achieve superlubricity if there are hydrogen ions attached on the friction surfaces. An ultra-low friction coefficient (μ = 0.004) of ethylene glycol between Si3N4 and SiO2 can be obtained with the effect of hydrogen ions. Experimental result indicates that the hydrogen ions ads...