A central goal of RNA sequencing (RNA-seq) experiments is to detect differentially expressed genes. In the ubiquitous negative binomial model for RNA-seq data, each gene is given a dispersion parameter, and correctly estimating these dispersion parameters is vital to detecting differential expression. Since the dispersions control the variances of the gene counts, underestimation may lead to fa...

The labels shrinkage-compensating , shrinkage-compensated and nonshrink found in the technical documentation of many proprietary repair materials are all intended principle to describe systems that exhibit no or little net contraction as a result shrinkage. In practice, however, these terms limited significance selection without appropriate test data on time-dependent volume changes. This paper...

Hans C. van Houwelingen Saskia le Cessie Department of Medical Statistics, Leiden, The Netherlands P.O.Box 9604 2300 RC Leiden, The Netherlands email: [email protected] Abstract A review is given of shrinkage and penalization as tools to improve predictive accuracy of regression models. The James-Stein estimator is taken as starting point. Procedures covered are the Pre-test Estimation, ...

This paper considers alternative estimators of the intercept parameter of the linear regression model with normal error when uncertain non-sample prior information about the value of the slope parameter is available. The maximum likelihood, restricted, preliminary test and shrinkage estimators are considered. Based on their quadratic biases and mean square errors the relative performances of th...

STATEMENT OF THE PROBLEM Polymerization shrinkage stress in composite restorations may lead to microleakage. Clinical methods such as using low-shrinkage composites have been suggested to overcome this problem; however, there are controversies about their efficiency in decreasing the microleakage. PURPOSE This in vitro study was conducted to compare the microleakage of two low-shrinkage resin...

Shrinkage behavior of a geopolymer cement paste prepared from pumice-type natural pozzolan was studiedby changing parameters of chemical composition including SiO2/Na2O molar ratio of activator and total molar ratiosof Na2O/Al2O3, and H2O/Al2O3. For investigating the effect of curing conditions on shrinkage, hydrothermal curingwas also applied. The obtained results clearly revealed the governin...

The purpose of this study is to evaluate the long-term vertical deformations of segmented pre-tensioned concrete bridges by a new approach. It provides a practical and reliable method for calculating the amount of long-term deformation based on creep and shrinkage in segmented prestress bridges. There are various relationships for estimating the creep and shrinkage of concrete. The analytical r...

Objective: Potato is the fourth important food crop after wheat, rice and maize. Shrinkage  of  food  materials  has  a negative  consequence  on  the  quality  of  the dehydrated product. The main objective pursued in this paper is to investigate the shrinkage amount of potato slices during drying process using vacuum-infrared method. Methods: In this work, the effect of the infrared radiation...