Background & Aim:Combretaceae family is   known for efficacy in the management of sickle cell disorder (SCD). Based on   the earlier reports of anti-sickling property of Terminalia genus the study investigates in vitro antisickling properties of Terminalia arjuna and Terminalia   bellirica. Experimental: Anti-sickling  ...

Background: Until now, trimodal distribution of HbS has been seen by six different studies in the world when associated with alpha-thalassemia with confirmation by corresponding alpha-genotyping studies. The RBC indices reduce as alpha-globin genes reduce in sickle cell trait (SCT) patients, which decreases the extent of intra-vascular sickling and thus betters the clinical cou...

BACKGROUND The aim of the study was to calculate the cost to the UK National Health Service of providing treatment services for patients with sickle cell disorders. The rates of differential morbidity and mortality, in the first 10 years of life, between screen-detected early diagnosed and clinically presenting late diagnosed cohorts of sickle cell disorder patients are also estimated. METHOD...

BACKGROUND Sickle cell disease (SCD) is a hereditary blood disorder prevalent in tribal regions of India. SCD can increase complications during pregnancy and in turn negatively influence pregnancy outcomes. This study reports the analysis of tribal maternal admissions in the community-based hospital of SEWA Rural (Kasturba Maternity Hospital) in Jhagadia block, Gujarat. The objective of the stu...

BACKGROUND AND OBJECTIVES Children with sickle cell disease are considered at high risk for complications from influenza infection and are recommended to receive annual influenza vaccination. However, data on the safety of influenza vaccination in children with sickle cell anemia are sparse. METHODS Using a retrospective cohort of children aged 6 months to 17 years in 8 managed care organizat...

Increased adherence of sickle erythrocytes to vascular endothelium has been suggested by Hebbel and his colleagues to play a role in vasocclusive events of sickle cell disease. To define the role of cell membrane changes and plasma factors in cell adherence, a micropipette technique previously developed by us to obtain a direct, quantitative measure of cell adherence was used to evaluate the ad...

In sickle cell disease transfusions improve blood flow by reducing the proportion of red cells capable of forming sickle hemoglobin polymer. This limits hemolysis and the endothelial damage that result from high proportions of sickle polymer-containing red cells. Additionally, transfusions are used to increase blood oxygen carrying capacity in sickle cell patients with severe chronic anemia or ...

RISKING REPRODUCTION:REPRODUCTIVE HEALTH AMONG WOMEN WITH SICKLE CELL DISEASEbyPAULA THOMPSON ROSSAugust 2013Advisor: Dr. Heather DillawayMajor: SociologyDegree: Doctor of PhilosophyReproductive health among women with sickle cell disease remains a critical gap in theliteratures on sickle cell disease, reproductive health, and women’s health. Sickle cell ...

By E. SILvEsTR0NI, M.D. AND I. BIANCO, M.D. S ICKLE CELL ANEMIA is a severe chromsic disease usually confined to the Negro race l ttt occasiotsally foutsd its imidividuals of the white race mostly of Southerti Italians on Greek stock. Clitsically there is chromsic hemolytic amsemia s ’iths crises, osteo-muscular pains, bouts of severe abcbomitsal pain and ulceratiomis of the legs. Hematological...