Simultaneous labeling of multiple targets in a single sample, or multiplexing, is a powerful approach to directly compare the amount, localization and/or molecular properties of different targets in the same sample. Here we highlight the robust reliability of the simultaneous use of multiple mouse monoclonal antibodies (mAbs) of different immunoglobulin G (IgG) subclasses in a wide variety of m...

DOUGLAS SHEIL*, AGUS SALIM*†, JÉRÔME CHAVE‡, JEROME VANCLAY§ and WILLIAM D. HAWTHORNE¶ * Center for International Forestry Research, PO Box 6596 JKPWB, Jakarta 10065, Indonesia, † National Centre for Epidemiology and Population Health, Australian National University, Mills Road, Acton ACT 0200, Australia, ‡ Laboratoire Evolution et Diversité Biologique, UMR CNRS 5174, 118, route de Narbone, F-3...

Again, for small degrees d, this is the kind of cancellation that we would expect from a sum of q random points on the unit circle. Looking at the whole argument in totality, what we just did is highly highly dependent on P (X) being a single monomial. The multiplicativity of the monomial brings the characters of the multiplicative group into play. For a general polynomial P (X), we have no suc...

In this paper, we will study an extreme case of cancellation over the rational function field k = E(T ). If we assume that the geometric Galois group Gal(k/kE) has no non-trivial invariants on V and that the degree f(V ) of the Artin conductor of V is twice the dimension of V , then L(V, s) is a polynomial of degree 0 in q with constant coefficient 1. Hence L(V, s) = 1 is a constant function! W...

We present a pedagogical derivation of the SachsWolfe effect, specifically the factor 3 relating the temperature fluctuations to gravitational potentials. The result arises from a cancellation between gravitational redshifts and intrinsic temperature fluctuations which can be derived from a coordinate transformation of the background.

Considering the BFKL and DGLAP QCD evolution equations for structure functions, we discuss the possibility of unifying them in the whole x and Q range. We emphasize that the main problem is related to the constraint of angular ordering of the radiation, and the cancellation of the related collinear singularities for inclusive processes. At the leading log 1/x and log Q level, we write down a un...

1Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden; 2Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD; 3Department of Medicine, McMaster University, Hamilton, ON; 4Department of Medicine, Section of Hematology and Coagulation, Sahlgrenska University...

Citation: Perezgonzalez JD (2015) The meaning of significance in data testing. are showing apparently reasonable but inherently flawed positions against data testing techniques (often called hypothesis testing techniques, even when they do not test hypotheses but assume them true for testing purposes). These positions are such as banning testing explicitly and most inferential statistics implic...

Multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) are plasma cell disorders of aging. The landscape of the diagnosis and management of MM and MGUS are rapidly changing. This article provides an updated understanding of the clinical presentation, evaluation, diagnosis, and management of older adults with MM and MGUS. Because most oncology providers are not forma...

The Significance Analysis of Microarrays (SAM) software is a very practical tool for detecting significantly expressed genes and controlling the proportion of falsely detected genes, the False Discovery Rate (FDR). However, SAM tends to find biased estimates of the FDR. We show that the same method with the data replaced by rank scores does not have this tendency. We discuss the choice of the r...