نتایج جستجو برای: silicosis

تعداد نتایج: 1318  

2017
Changjiang Xue Na Wu Xue Li Meihua Qiu Xuqin Du Qiao Ye

BACKGROUND Asbestosis and silicosis are progressive pneumoconioses characterized by interstitial fibrosis following exposure to asbestos or silica dust. We evaluated the potential diagnostic biomarkers for these diseases. METHODS The serum concentrations of Krebs von den Lungen-6 (KL-6), surfactant protein D (SP-D), and matrix metalloproteinase-2 (MMP-2), MMP-7, and MMP-9 were measured in 43 ...

2014
Diemen Darwin Delgado

In many countries, the work of mining, quarrying, construction of tunnels and galleries, abrasive jet cleaning and smelting continue to present significant risks of silica exposure and silicosis epidemics still occur, even in developed countries. Patients with silicosis are particularly susceptible to opportunistic lung infections such as aspergillosis and tuberculosis. Occasionally silicosis i...

Journal: :BMJ case reports 2015
V Murlidhar

Silicosis from secondary exposure is not often reported. This is the first such report of a child with possible silicosis attributable to secondary exposure to sandstone mining in India. Silicosis from secondary exposure has been reported in the gem polishing and slate pencil manufacturing industries in India; however, the stone-mining industry is severely under-researched. No preventive measur...

Journal: :Journal of dermatology and skin science 2022

Dermatological manifestations of connective tissue diseases (CTDs) are common and frequently precede other symptoms. Thus, dermatologists may be the first clinicians to diagnose these disorders. Silica exposure is an acknowledged cause several CTDs, but this under-appreciated by clinicians, who also unaware wide range jobs in which silica can occur. The CTDs associated with include systemic scl...

Journal: :Romanian Journal of Occupational Medicine 2022

Abstract Background: Historically, silicosis is a disease of miners, but the last decade witnessed outbreaks in occupational settings not traditionally associated with silica exposure. Evidence from other countries may ground awareness and control re-emergent risks. Methods: Incident cases diseases, ranking trends were analysed within period 2005-2016 using cross-national comparative study. Lab...

2016
Wang Xiaojun Liu Yan Xu Hong Zhang Xianghong Li Shifeng Xu Dingjie Gao Xuemin Zhang Lijuan Zhang Bonan Wei Zhongqiu Wang Ruimin Darrell Brann Yang Fang

Silicosis is the most serious occupational disease in China. The objective of this study was to screen various proteins related to mechanisms of the pathogenesis of silicosis underlying the anti-fibrotic effect of N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) using proteomic profile analysis. We also aimed to explore a potential mechanism of acetylated α-tubulin (α-Ac-Tub) regulation by Ac-SD...

2013
Zhanzhan Li Jing Xue Shipeng Yan Peng Chen Lizhang Chen

BACKGROUND Tumor necrosis factor-α (TNF-α) 308 G/A gene polymorphism has been reported to be associated with susceptibility to silicosis. However, the relevant study results are still inconsistent. OBJECTIVE AND METHODS A meta-analysis was performed in order to drive a more precise estimation of the relationship between TNF-α-308 G/A gene polymorphism and susceptibility to silicosis. Electron...

2017
Jacek M. Mazurek John M. Wood Patricia L. Schleiff David N. Weissman

Silicosis is usually a disease of long latency affecting mostly older workers; therefore, silicosis deaths in young adults (aged 15-44 years) suggests acute or accelerated disease.* To understand the circumstances surrounding silicosis deaths among young persons, CDC analyzed the underlying and contributing causes† of death using multiple cause-of-death data (1999-2015) and industry and occupat...

2016
Fangwei Liu Wujing Dai Chao Li Xiaowei Lu Ying Chen Dong Weng Jie Chen

Silicosis is characterized by chronic lung inflammation and fibrosis, which are seriously harmful to human health. Previous research demonstrated that uncontrolled T-helper (Th) cell immune responses were involved in the pathogenesis of silicosis. Lymphocytes also are reported to have important roles. Existing studies on lymphocyte regulation of Th immune responses were limited to T cells, such...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2000
R W Spech P Wisniowski D L Kachel J R Wright W J Martin

Silicosis is a serious occupational lung disease associated with irreversible pulmonary fibrosis. The interaction between inhaled crystalline silica and the alveolar macrophage (AM) is thought to be a key event in the development of silicosis and fibrosis. Silica can cause direct injury to AMs and can induce AMs to release various inflammatory mediators. Acute silicosis is also characterized by...

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