background: defects in endoplasmic reticulum homeostasis are common occurrences in different diseases, such as diabetes, in which the function of endoplasmic reticulum is disrupted. it is now well established that ion channels of endoplasmic reticulum membrane have a critical role in endoplasmic reticulum luminal homeostasis. our previous studies showed the presence of an atp-sensitive cationic...

introduction: intracellular ph (phi) regulates essentially all aspects of cellular activities. however, it is unknown how endoplasmic reticulum (er) potassium channels sense phi. in this study, we investigate the direct effects of phi on er potassium channels. methods: we used channel incorporation into the bilayer lipid membrane method. l-α-phosphatidylcholine, a membrane lipid, was extracted ...

We present a model for time-varying communication single-access and multiple-access channels without feedback. We consider the difference between mutual information when the receiver knows the channel perfectly and mutual information when the receiver only has an estimate of the channel. We relate the variance of the channel measurement error at the receiver to upper and lower bounds for this d...

Voltage-gated ion channels are key players in fast neuronal signalling. Detailed knowledge about channel gating is essential for our understanding of channel function in general and of drug action of channels in particular. Despite a number of recent atomic channel structures, the opening of voltage-gated channels is the subject of heated debates. Here we will discuss two of the controversies: ...

open-channel junctions have a broad application in civil and environmental engineering. formation of a low-pressure zone with recirculating flow (high sedimentation) accompanied by a high-velocity zone (high erosion) is the most characteristic feature of flow in junctions. a large number of researches have been performed to study the complexity of the flow in junctions in open-channel flows. in...

in this paper, the problem of turbulent forced convection flow of water- alumina nanofluid in a uniformly heated pipe has been thoroughly investigated. in numerical study, single and two-phase models have been used. in single-phase modeling of nanofluid, thermal and flow properties of nanofluid have been considered to be dependent on temperature and volume fraction. effects of volume fraction a...

This paper reports on the design and analysis of a novel thermal single-axis microelectromechanical gyroscope. The gyroscope consists of a heated, pressure driven liquid flowing in a microchannel and two temperature sensors that detect the temperature difference between the two opposite walls of the channel. When an external rotation is applied, the resulting Coriolis acceleration acting on the...