to assess the association between polymorphisms of the il-6 -174 g/c and behçet's disease (bd) in tunisian patients. dna was extracted from blood samples taken from 43 tunisian patients and 43 healthy controls. the polymorphisms were analyzed by pcr with the pcr-rflp. no significant association was found between patients and controls concerning polymorphism of il6 -174 g/c between the (allelic ...

Abstract Background Some ultrasonic soft markers can be found during ultrasound examination. However, the etiology of fetuses with is still unknown. This study aimed to evaluate genetic and clinical value chromosomal abnormalities copy number variations (CNVs) in markers. Methods Among 1131 fetuses, 729 had single marker, 322 two markers, 80 three or more All underwent conventional karyotyping,...

background: coronary artery disease (cad) is a multifactorial and heterogenic disease. recently, genome-wide association studies have reported that rs1333040 (c/t) and rs1004638 (a/t) single nucleotide polymorphisms (snps) in the 9p21 locus have very strong association with cad. this study aimed to examine these associations in southwest of iran. methods: blood samples were collected from 200 c...

UNLABELLED The high cost of genotyping single nucleotide polymorphisms (SNPs) generally prohibits the systematic mapping of entire genetic linkage regions in order to find the polymorphisms associated with increased risk of disease. In practice, SNPs are selected at approximately equal spacing across the linkage region to try to locate a SNP lying in the haplotype block of the disease SNP. The ...

Genome wide association studies (GWAS) are an important approach to understanding the genetic mechanisms behind human diseases. Single nucleotide polymorphisms (SNPs) are the predominant markers used in genome wide association studies, and the ability to predict which SNPs are likely to be functional is important for both a priori and a posteriori analyses of GWA studies. This article describes...

During last years there has been a breakthrough in genetics and biotechnology. Present technology allows large scale association studies between genotypes and diseases. The most powerful methodology of association studies is the analyse of single nucleotide polymorphisms (SNPs). The estimated number of SNPs in the human genome is 10 million. Therefore, SNP markers provide practical fine-grain m...

The use of the three genetic models viz. additive, dominant and recessive in Genome-wide association study (GWAS) is a common powerful approach to between variants trait (disease). selection these depends on pattern inheritance scope study. GWAS typically focuses single-nucleotide polymorphism (SNPs) human diseases case-control setup. In order this type risk genotype phenotype for given pattern...

Daphnia magna belongs to the Cladocera and plays an important role in water ecosystem. With intensification of pollution, wild population D. has declined rapidly recent years, insufficient molecular markers have limited effective research conservation this species. In research, 30 novel single nucleotide polymorphism (SNP) were developed a cultivar 12 using restriction site-associated DNA seque...

The dojo loach Misgurnus anguillicaudatus is an endemic freshwater species in Asia. effective conservation and molecular-aided selection of M. were limited without sufficient molecular markers. In this study, 112 novel single nucleotide polymorphism (SNP) markers screened based on 2b-RAD sequencing database, 56 SNPs them developed characterized by genotyping 40 individuals using SNaPshot method...

The purpose of this study was to investigate whether an association exists between the promoter region of the prostacyclin synthase gene and essential hypertension (EH). Using the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) method, we discovered a novel single nucleotide polymorphism (SNP), T-192G, in the 5'-flanking region. We performed an association study usi...