Contemporary management of chronic wounds focuses on improving natural healing and individualization of treatment. Incorporating multiple therapies has become increasingly common. Of interest are autologous growth factors, which are especially important in chronic wound healing and may contribute to tissue formation and epithelialization. Autologous platelet concentrate or platelet-rich plasma ...

INTRODUCTION Glycerol preserved acellular dermis (Glyaderm(®)) consists of collagen and elastin fibers and is the first non-profit dermal substitute derived from glycerol-preserved, human allogeneic skin. It is indicated for bi-layered skin reconstruction of full thickness wounds. METHODS A protocol for clinical application and optimal interval before autografting with split thickness skin gr...

Preformulation studies on transdermal dosage forms involve liberal use of animal skin for assessing the permeation characteristics of drugs, influence of permeation enhancers, optimizing the formulation variables etc. The restricted availability of animal skin due to concerns regarding prevention of cruelty to animals has generated considerable interest in developing polymeric films for use as ...

Preformulation studies on transdermal dosage forms involve liberal use of animal skin for assessing the permeation characteristics of drugs, influence of permeation enhancers, optimizing the formulation variables etc. The restricted availability of animal skin due to concerns regarding prevention of cruelty to animals has generated considerable interest in developing polymeric films for use as ...

We present a case of scalp reconstruction using Integra and split skin grafting after extensive excision of melanoma in a previously irradiated field. Radical resection of malignancy and application of Integra, a dermal substitute, was performed. Following histological confirmation of complete excision, a split-thickness skin graft (SSG) was applied. After 14 months the patient remains fully he...

To assess the usefulness of Mycobacterium leprae-infected armadillo tissue as a substitute for human lepromas for the manufacture of lepromin, we compared skin reactions to preparations from these two sources in 115 leprosy patients. The patient sample represented all the primary clinical forms of leprosy. Lepromin derived from the armadillo (lepromin-A) provoked the same pattern of responses a...