نتایج جستجو برای: sle
تعداد نتایج: 10032 فیلتر نتایج به سال:
The objective of the study was to assess the frequence of serum IgG anti-neuronal antibodies (NA) in SLE patints with CNS manifestations. Serum anti-NA antibodies were measured in 47 patients with SLE with CNS manifestations (CNS-SLE), age 33-52 years, mean age 38.6 years, 18 men and 29 women, as compared to 31 patients with SLE without CNS manifestations, age 28-56 years, mean age 41.2 years, ...
BACKGROUND Women with systemic lupus erythematosus (SLE) have premature and accelerated atherosclerosis. Although percutaneous coronary intervention (PCI) is used frequently to treat coronary artery disease in SLE, little is known regarding PCI outcomes immediately after PCI and after discharge. METHODS AND RESULTS Baseline demographic, procedure-related, and adverse outcome data on consecuti...
Systemic lupus erythematosus Systemic lupus erythematosus (SLE) is characterized by the presence of several autoantibodies, including anti-dsDNA antibodies [1,2]. Patients with SLE are affected with the following conditions: skin rash, arthritis, serositis, such as pericarditis and pleurisy, cytopenia, nephritis and neuropsychiatric (NP) symptoms. The prevalence of SLE ranges from 20 to 200 cas...
Background: Different criteria have been used for classification of SLE as ACR and BW criteria (BW). In BW criteria every item has score. The outcome of this study is comparison of ACR with BW criteria diagnosis of SLE. Methods: All SLE patients who referred to rheumatology clinic of Rasool Akram hospital were enrolled in this study that was from 2004 to 2006. All data recorded of medical f...
OBJECTIVE To investigate the association of interleukin 10 (IL10) promoter polymorphisms and neuropsychiatric manifestations of systemic lupus erythematosus (SLE). METHODS IL10 haplotypes of 11 healthy volunteers were cloned to confirm that in the Dutch population, only the three common haplotypes (-1082/-819/-592) GCC, ACC and ATA exist. The IL10 promoter polymorphisms of 92 SLE patients and...
BACKGROUND Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder which can affect multiple organs of the body, requiring ongoing disease management and healthcare resource utilization. The economic impact of SLE has not been evaluated in a Medicare population to date. This study was conducted to assess the prevalence of SLE and its burden in terms of healthcare resource utilizatio...
OBJECTIVE SLE is more prevalent in females, but may cause more severe organ damage in males. The underlying mechanism is incompletely understood. Since macrophage plays a key role in SLE pathogenesis, the present work aimed to investigate whether inflammasomes in male and female SLE macrophages are differentially activated. METHODS Macrophages were derived from peripheral blood mononuclear ce...
OBJECTIVE To assess the risk factors for leukaemic transformation and myeloid leukaemia in patients with SLE. METHODS A national SLE cohort identified through SLE discharge diagnoses in the Swedish hospital discharge register during 1964 to 1995 (n = 6438) was linked to the national cancer register. A nested case-control study in SLE patients who developed acute or chronic myeloid leukaemia w...
Systemic lupus erythematosus (SLE) is a clinically heterogeneous, systemic autoimmune disease characterized by autoantibody formation. Previously published genome-wide association studies (GWAS) have investigated SLE as a single phenotype. Therefore, we conducted a GWAS to identify genetic factors associated with anti-dsDNA autoantibody production, a SLE-related autoantibody with diagnostic and...
OBJECTIVE Systemic lupus erythematosus (SLE) and other autoimmune diseases cause significant morbidity. Identifying populations at risk of developing SLE is essential for curtailing irreversible inflammatory damage. The aim of this study was to identify factors associated with transition to classified disease that would inform our understanding of the risk of SLE. METHODS Previously identifie...
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