OBJECTIVES To evaluate the effects of adjunctive pregabalin 300 mg/day versus placebo on polysomnographic (PSG) variables in patients with well controlled partial seizures and subjectively reported sleep disturbance. METHODS An exploratory, 4-week, double-blind, randomized study in patients with well controlled partial seizures on AED monotherapy and subjective sleep disturbance over the prev...

STUDY OBJECTIVES To determine whether the duration of sleep, sleep quality, insomnia, or sleep disturbance was associated with incident breast cancer in the Women's Health Initiative (WHI). DESIGN Prospective cohort study. SETTING Women enrolled in one of the Clinical Trial (CT) arms or the Observational Study (OS) from the WHI conducted in the United States. PARTICIPANTS This study inclu...

BACKGROUND Sleep disturbance is a common clinical complaint of oncology patients and contributes to substantial morbidity. However, because most sleep studies have been cross-sectional, associations between sleep quality and distress in patients with ovarian cancer over time remain unclear. This prospective longitudinal study examined rates of sleep disturbance; contributions of depression, anx...

PURPOSE/OBJECTIVES To describe the pain experience of outpatients with cancer and explore the relationships with sleep disturbance, depression, and patient functioning. DESIGN Descriptive, cross-sectional study. SETTING Outpatient clinics at a large comprehensive cancer center in the southeastern United States. SAMPLE 85 patients with a pain intensity level of at least 3. METHODS Second...

1378 CAFFEINE IS A WIDELY USED STIMULANT WITH MARKED VARIATIONS IN BEHAVIORAL RESPONSE BETWEEN INDIVIDUALS. POSITIVE BEHAVIORAL responses may include increased alertness and physical activity, although these may represent a withdrawal reversal mechanism operating in habitual caffeine users,1-3 whereas responses such as heightened nervousness and sleep disturbance would be considered negative.4-...

To examine the association between sleep disorders, obesity status, and the risk of diabetes in adults, a total of 3668 individuals aged 40+ years from the NHANES 2009-2010 without missing information on sleep-related questions, measurements related to diabetes, and BMI were included in this analysis. Subjects were categorized into three sleep groups based on two sleep questions: (a) no sleep p...

OBJECTIVES To examine the contribution of sleep disturbance to cognitive performance following blast exposure. DESIGN Correlational research evaluating self-reported sleep disturbance as a mediator of the association between the primary blast-related comorbidities of mild traumatic brain injury (mTBI) and posttraumatic stress disorder and cognitive outcome. PARTICIPANTS One hundred sixty Op...

OBJECTIVES To examine the effects of racism on sleep disturbance and depression and to examine whether sleep disturbance mediates the effects of racism on depression. DESIGN Cross-sectional questionnaire study. SETTING Community. PARTICIPANTS 168 Hispanic-American immigrants, 45% female, average age 33 years, average length of time living in the United States was 5 years. MEASURES The P...

Study Objectives The aims of this study were to document sleep disturbances in individuals with Phelan-McDermid syndrome (PMS), to assess whether these individuals had been evaluated for sleep disorders, and to examine relationships between the sleep behavior of these individuals and the sleep behavior and daytime functioning of their caregivers. Methods Participants were 193 caregivers of in...

OBJECTIVE To describe the frequency of reported sleeping, depression and pain problems, the severity of these problems and the degree of self-estimated difficulties in mental functions and activities in relation to the sleep disturbance and pain category group in patients on long-term sick-leave. DESIGN Cross-sectional study. PATIENTS A total of 1206 patients experiencing difficulty in resu...