WV TITHIN the past few years it has been repeatedly suggested that the sodium retention occurring in patients with circulatory failure (both cardiac and peripheral) was the result of inadequacy of cardiac output. Such inadequacy has been thought by some to cause sodium retention as the result of decline in glomerular filtration.1' 2, 9, 10 Others have assumed that the retention was due to incre...

The mechanism of diminished sodium excretion induced by propranolol was investigated in the dog. Propranolol (0.3 to 5 mg/kg) was given intravenously in a bolus to 16 dogs, eight of which had the renal perfusion pressure controlled by a suprarenal aortic clamp. In another group of six dogs propranolol (0.1 to 5 ,ug/kg/min) was infused into one renal artery for 45 min. Cardiac output (dye diluti...

Metabolic acidosis often accompanies low glomerular filtration rate and induces secretion of endothelin, which in turn might mediate kidney injury. Here we tested whether treatment of metabolic acidosis in patients with low glomerular filtration rate reduced the progression of kidney disease. Fifty-nine patients with hypertensive nephropathy and metabolic acidosis had their blood pressure reduc...

Sera from chronically uremic and normal individuals were subjected to gel filtration with Sephadex G-25 and the same fraction of both was infused into rats with a decreased nephron population to determine the effects on sodium excretion. Sodium excretion rate and fractional sodium excretion increased slightly with the normal fractions; but the increase in both functional parameters produced by ...

1. Renal function in anaesthetized Brattleboro rats with hereditary hypothalamic diabetes insipidus was studied with micropuncture techniques before, and 1-3 h after, a single injection of hydrochlorothiazide. 2. In rats given hydrochlorothiazide and kept in sodium and water balance, total glomerular filtration rate and superficial nephron filtration rate were similar to values in control anima...

Peptides from soybean meal were subjected to extrusion and the effects of extrusion conditions, such as moisture of the materials, barrel temperature, screw speed and nozzle diameter, on the antioxidant properties were studied. The extrusion conditions that had the highest free radical-scavenging activity were further separated into three peptide fractions (using ultra filtration); hydrolysis o...

Two membrane electrochemical reactors (MER) were designed and applied to HLADH-catalysed reduction of cyclohexanone to cyclohexanol. The regeneration of the cofactor NADH was ensured electrochemically, using either methyl viologen or a rhodium complex as electrochemical mediator. A semi-permeable membrane (dialysis or ultra-filtration) was integrated in the filter-press electrochemical reactor ...

Experimental Reagents and chemicals m-Phenylenediamine (mPDA >99%) was purchased from Acros Organics, ethylenediamine (EDA, Sigma Ultra) was obtained from Sigma Aldrich. ortho-Phosphoric acid (85%, ACS certified) was purchased from Fisher Scientific. All the other chemicals were of analytical grade. Buffer solutions with different pH were prepared using chemicals (such as sulphuric acid, citric...

Blood pressure follows a circadian rhythm with a physiologic 10% to 20% decrease during the night. There is now increasing evidence that a blunted decrease or an increase in nighttime blood pressure is associated with a greater prevalence of target organ damage and a faster disease progression in patients with chronic kidney diseases. Several factors contribute to the changes in nighttime blood...

Wastes generated from the processing of some fruits still contain large amounts of chemical components such as polyphenols, which are deemed as very effective antioxidants.This study involves the characterization of wastes generation by pink guava processing and selection of the best solvent that will allow us to extract the excess polyphenols via ultra-filtration membran...