CONTEXT Contrast-induced nephropathy remains a common complication of radiographic procedures. Pretreatment with sodium bicarbonate is more protective than sodium chloride in animal models of acute ischemic renal failure. Acute renal failure from both ischemia and contrast are postulated to occur from free-radical injury. However, no studies in humans or animals have evaluated the efficacy of s...

This report aims to look at the role of Sodium bicarbonate as a potent Ergogenic aid and its role in improving the performance of athletes. It includes the mechanism of action of sodium bicarbonate during high-intensity exercise. The report also shows the various types of athletes who can be benefited from sodium bicarbonate loading, evidences for improvement in performance, conflicting evidenc...

of jellyfish that causes the sting, it can be useful to apply vinegar, a 1:1 aqueous solution of sodium bicarbonate, or a saturated solution of magnesium sulfate in a solution of sodium chloride. Jellyfish sting reactions are very common on the Spanish coast in summer. Therefore, although these reactions tend to be local and short-lasting, we consider it important to know how to deal with them ...

This report attempts to frame the debate about clinical administration of sodium bicarbonate in the setting of lactic acidosis in terms of simple questions. Specifically, we address why we develop lactic acidosis in some circumstances, how acute lactic acidosis impairs cardiovascular function and why sodium bicarbonate may have deleterious effects which limit its utility. We also attempt to exp...

Flecainide is a class Ic anti - arrhythmic drug with sodium channel blocking activities. We report a case of a 57 year - old woman who attempted a suicide by ingesting approximately 1,8 gr of flecainide. On the surface electrocardiogram this results in a large QRS complex and in prolongation of the QTc interval. Overdose with a class Ic drug is very uncommon, its management is difficult and the...

BACKGROUND Vascular access in children carries a significant risk of accidental extravasation of IV fluids and medications with the potential for tissue injury. In this prospective controlled study we assessed the diagnostic utility of using IV diluted sodium bicarbonate to confirm placement of IV catheters in ventilated children. Diluted sodium bicarbonate was created using undiluted standard ...

BACKGROUND The regulation of fibroblast growth factor-23 (FGF23) secretion in patients with chronic kidney disease (CKD) is incompletely understood. An in vitro study showed that metabolic acidosis increased FGF23 in mouse bone. The objective of this study is to evaluate the effect of oral sodium bicarbonate on circulating FGF23 levels in patients with CKD. METHODS This was a single-blind pil...

Lactic acidosis often challenges the intensivist and is associated with a strikingly high mortality. Treatment involves discerning and correcting its underlying cause, ensuring adequate oxygen delivery to tissues, reducing oxygen demand through sedation and mechanical ventilation, and (most controversially) attempting to alkalinize the blood with IV sodium bicarbonate. Here we review the litera...

I Siewert M, Gnekow H. Uber die Stabilitat von Glucose-Elektrolyt-Mischungen (oral rehydration salts: ORS) zur Therapeutie von Durchfallerankungen). Phartnazeutische Zeitung 1983;128: 1169-74. 2 Hoffman SL, Moechtar MA, Simajutank C, et al. Rehydration and maintenance therapy of cholera patients in Jakarta: citrate-based versus bicarbonate-based oral rehydration salt solution. J Infect Dis 1985...

OBJECTIVE The goal of this study was to compare the dissolving potential of Dakin's solution with that of equivalent buffered and unbuffered sodium hypochlorite solutions on fresh and decayed tissues. In addition, the antimicrobial effect of Dakin's solution and equivalent unbuffered hypochlorite was tested. STUDY DESIGN Tissue specimens were obtained from freshly dissected pig palates. Unbuf...