p63 is a p53 homolog that is expressed in various normal epithelial tissues and epithelial malignancies. Its expression in mesenchymal lesions has not been examined in depth; therefore, we studied p63 expression by immunohistochemical analysis in 650 soft tissue tumors. We found that p63 expression is limited in soft tissue tumors. The majority of tumors studied were p63-, including all cases o...

Introduction The term soft tissue tumours is used to describe a heterogeneous group of neoplasms that exhibit the differentiated features of various supporting tissues of the body, such as smooth and striated muscle, fat, fibrous tissue and vessels (1). Together with tumours of bone, they form a major histogenetic class distinct from neoplasms of epithelial origin (adenomas and carcinomas), blo...

Low-grade fibromyxoid sarcoma (LGFMS) is a rare, typically deep-seated soft tissue neoplasm with deceptively bland cytology and metastatic potential. A t(7;16)(q34;p11) translocation, yielding a FUS/CREB3L2 fusion gene, has been identified in approximately 80%-90% of deep soft tissue LGFMS. Cutaneous fibromyxoid neoplasms occur not infrequently; dermatopathologists rarely consider LGFMS in the ...

Soft tissue sarcomas are a heterogeneous group of malignant neoplasms of mesenchymal origin. They account for approximately 1% of all cancer diagnoses and 7% of pediatric malignancies (1,2). Just over half of these patients eventually succumb as a result of the disease. Soft tissue sarcomas typically present as asymptomatic large masses within the retroperitoneum or the proximal lower limbs but...

Musculoskeletal system neoplasms must be accessed by a multidisciplinary clinical team, comprised by an orthopedic oncologist, a pathologist and a radiologist. Most of times, the central question to be answered before treatment is whether the tumor has malignant characteristics or not. After treatment, the question shifts to whether the tumor has been completely resected or destroyed and if the...

statement of the problem: most of the soft tissue calcifications within the head and neck region might not be accompanied by clinical symptoms but may indicate some pathological conditions. purpose: the aim of this research was to determine the prevalence of soft tissue calcifications in cone beam computed tomography (cbct) images of mandibular region. materials and method: in this cross sectio...

Extraskeletal Ewing's sarcoma (EES) is a type of Ewing's sarcoma that arises in soft tissue and is now regarded as a member of a family of small round cell neoplasms of bone and soft tissue, including primitive neuroectodermal tumors (PNETs). EES occurs predominantly in adolescents and young adults between the ages of 10 and 30 years. The disease follows an aggressive course with a high recurre...

Prostate adenocarcinoma is the most common malignancy and the second leading cause of cancer related deaths in men. Testicular liposarcomas are uncommon soft tissue neoplasms. We report coexistence of prostate cancer and testicular liposarcoma in a 69 year-old-man because while orchiectomy endications are decreasing day by day, these second malignancies should not be missed.

A 21 year old female presented with incidental findings of complex anterior mediastinal mass. This patient was otherwise healthy, without contributory medical, surgical, family or social history. CT imaging identified a right paracardiac mediastinal mass with components of variable attenuation, including fluid, soft tissue and fat components. Mediastinal mature teratoma was suspected. Cystic or...

The commonly seen primary malignant neoplasms of the spleen are angiosarcoma and lymphoma. We present a case of serous cystadenocarcinoma of the spleen. It was presumed to be originated from dropped nonmalignant ovarian tissue, which was accidentally implanted to the splenic surface during hysterectomy and bilateral salpingooophorectomies for torsion of right fallopian tube 9 and half years ago...