Solubility plays a major role in protein purification, and has serious implications in many diseases. We studied the effects of pH and mutations on protein solubility by calculating the transfer free energy from the condensed phase to the solution phase. The condensed phase was modeled as an implicit solvent, with a dielectric constant lower than that of water. To account for the effects of pH,...

Eye drops in the form of an aqueous solution with a lower viscosity are preferred for local administrations in ophthalmology. In ophthalmic formulations, cyclodextrins (CDs) are frequently used in recent years in order to increase water solubility, stability and bioavailability of an active substance and decrease an irritation to the eye. The scope of the present study was to investigate the in...

BACKGROUND The purpose of this study was to develop, characterize, and investigate a molecular inclusion complex containing rifaldazine with good solubility and antibacterial activity. METHODS Rifaldazine, a lipophilic molecule, was encapsulated into the hydrophobic cavity of β-cyclodextrin to form a molecular inclusion complex (RAABCD) with good solubility. RAABCD was prepared in a short tim...

A novel approach using a semipermeable Teflon AF-2400 tube-in-tube membrane contactor was developed for the measurement of gas solubility in organic solvents. This membrane ensures gas saturation of liquids in continuous flow at a specific pressure and temperature. After liquid decompression, the amount of gas outgassed was measured with a bubble meter and used for solubility calculation. The p...

AIM This study aimed to compare the solubility of a universal restorative resin composite (Filtek Z250; FZ250) and a silorane-based resin composite (Filtek Silorane; FS) after immersion in alcohol-containing mouthrinse, alcohol-free mouthrinse, and artificial saliva. METHODS 30 discs (10 mm × 1 mm) were prepared from each material and desiccated until a constant mass was obtained. Specimens w...

Let (V, g) and (W,h) be compact Riemannian manifolds of dimension at least 3. We derive a lower bound for the conformal Yamabe constant of the product manifold (V × W, g + h) in terms of the conformal Yamabe constants of (V, g) and (W,h).