Neuroendocrine tumors (NET) is a rare pathology characterized by dysfunction of the pituitary gland and endocrine glands. The survival prognosis depends on stage disease at which malignant growth was detected. study objective to summarize information methods early diagnosis NETs antitumor therapy using peptide hypothalamic hormone somatostatin analogues. review provides chronological analysis s...

The discovery of the new properties of SSRs and DRs has led to a renewed interest in agents targeting these receptors and has opened new perspectives for medical treatment of patients with pituitary and neuroendocrine tumors resistant to the “classical”, currently available analogs. Moreover, SSRs and DRs crosstalk at membrane level may trigger alternative intracellular pathways or enhance the ...

Copyright: © 2013 Kumar U. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abbreviations: β1 and β2 AR: Adrenergic Receptors; cAMP: Cyclic Adenosine Mono Phosphate; CGRP: Calcitonin Gene Related Peptide; CHO-K...

In this study, we investigated the relationship between affinity to somatostatin receptor subtype2 (SSTR(2)) and uptake of radioactivity from a group of radiolabeled somatostatin analogues in somatostatin receptor-rich tissues of rats. Organs with a high density of somatostin receptors (namely the adrenals and pancreas bearing mainly SSTR(2); this receptor subtype is also the most abundant in s...

The peptide somatostatin is one of many neuroactive agents that influence retinal physiology. It is synthesized primarily in a subclass of amacrine cells and believed to function as a neurotransmitter, neuromodulator or trophic factor. The cloning of the somatostatin receptors (sst1-5) in the early nineties provided the appropriate tools for the study of ssts in many tissues, including the reti...

We characterized structurally the receptors for somatostatin in rat cerebral cortex by affinity labeling with [125I-Tyr1] somatostatin. [125I-Tyr1] somatostatin was cross-linked to cerebrocortical membranes using photoreactive cross-linker: N-5-azido-2-nitrobenzoyloxy-succinimide. Analysis by autoradiography revealed a broad band centered at Mr = 72,000 in the presence or absence of dithiothrei...