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AIMS Beta-adrenergic augmentation of Ca(2+) sparks and cardiac contractility has been functionally linked to phosphorylation-dependent dissociation of FK506 binding protein 12.6 (FKBP12.6) regulatory proteins from ryanodine receptors subtype 2 (RYR2). We used FKBP12.6 null mice to test the extent to which the dissociation of FKBP12.6 affects Ca(2+) sparks and mediates the inotropic action of is...

BACKGROUND Preventive child health care is well suited for the early detection of parenting and developmental problems. However, as far as the younger age group is concerned, there are no validated early detection instruments which cover both the child and its environment. Therefore, we have developed a broad-scope structured interview which assesses parents' concerns and their need for support...

Recently, Spark as data processing engine, gained huge popularity because of better performance in terms of the speed. Developers of Spark claim that it may outperform Hadoop MapReduce in 100 times in memory and 10 times on disk [1]. This paper outlines which innovations improved speed and how. In order to investigate improvements, I analysed technical documentation, which is available, since b...

Maximization of the fuel economy of the lean burn spark ignition (SI) engine strongly depends on precise air-fuel ratio control. A great challenge associated with the air-fuel ratio feedback control is the large variable time delay in the exhaust system. In this paper, a systematic development of an air-fuel ratio controller based on post lean NOx trap (LNT) oxygen sensor feedback using linear ...

The efficiencies of methods employed in solution of building simulation models are considered and compared by means of benchmark testing. Direct comparisons between the Simulation Problem Analysis and Research Kernel (SPARK) and the HVACSIM+ programs are presented, as are results for SPARK versus conventional and sparse matrix methods. An indirect comparison between SPARK and the IDA program is...

AIMS: β-adrenergic augmentation of Ca 2+ sparks and cardiac contractility has been functionally linked to phosphorylation–dependent dissociation of FK506 binding protein 12.6 (FKBP12.6) regulatory proteins from ryanodine receptors subtype 2 (RYR2). We used FKBP12.6 null mice to test the extent to which the dissociation of FKBP12.6 affects Ca 2+ sparks and mediates the inotropic action of isopro...