Cardiac Resynchronization Therapy in Women Versus Men: Observational Comparative Effectiveness Study From the National Cardiovascular Data Registry Robbert Zusterzeel, MD; Erica S. Spatz, MD, MHS; Jeptha P. Curtis, MD; William E. Sanders, MD, MBA; Kimberly A. Selzman, MD, MPH; Ileana L. Piña, MD, MPH; Haikun Bao, PhD; Angelo Ponirakis, PhD; Paul D. Varosy, MD; Frederick A. Masoudi, MD, MSPH; Da...

Pantothenate kinase 2 deficiency (previously known as Hallervorden-Spatz disease) is an unusual metabolic disorder characterized by progressive extrapyramidal dysfunction and dementia. A 27-year-old Caucasian presented with a major depression disorder and social phobia since adolescence. Patient had marked paranoia, auditory hallucinations, extrapyramidal dysfunction, poor memory, and gait abno...

PURPOSE To compare the MR findings of eight cases with clinical diagnosis of Hallervorden-Spatz disease (HSD) with the pathologic findings of two other cases of HSD. MATERIALS AND METHODS The eight imaged cases were studied with 0.5-T (seven cases) and/or 1.5-T (five cases) units. Six patients also had CT scans. The two other cases with proven HSD had detailed histologic evaluation. RESULTS...

Robert L. McNamara, MD, MHS;* Erica S. Spatz, MD, MHS;* Thomas A. Kelley, MD, MBA; Caleb J. Stowell, MD; John Beltrame, MD, PhD; Paul Heidenreich, MD, MS; Ricard Tresserras, MD, PhD, MPH; Tomas Jernberg, MD, PhD; Terrance Chua, MD; Louise Morgan, MSN; Bishnu Panigrahi, MD; Alba Rosas Ruiz, PhB, MPharm; John S. Rumsfeld, MD, PhD; Lawrence Sadwin, BS; Mark Schoeberl, MPA; David Shahian, MD; Clive...

The brain uses iron for many essential processes (1-4). The extent of iron utilization is heavily dependent on local functional requirements, leading to significant variations in tissue iron concentrations throughout the brain (5-7). This was graphically illustrated nearly a century ago in the first colour illustrations of the differential distribution of iron throughout the brain architecture,...