objectives major differences exist in the anatomy and biomechanics of the growing spine that causes failure patterns different from those in adults. spinal injury in the pediatric patient is a main concern because timely diagnosis and appropriate treatment can prevent further neurologic damage and deformity and potentiate recovery. we conducted a retrospective clinical study of 137 cases (93 bo...

background: recent reports demonstrated that intravenous route as a minimally invasive method, similar to direct injection, is suitable for bone marrow stromal cell (bmsc) transplantation. in this study, we made a comparison of intraspinal and intravenous route of bmsc administration to repair injured spinal cord tissue. methods: six groups of adult female rats were used in this study. laminect...

introduction deep vein thrombosis is one of the most important complications in patients with spinal cord injury. this study compares the effects of mechanical prophylaxis with or without pharmacological prophylaxis on prevention of deep vein thrombosis in patients with spinal cord injury. materials and methods we conducted a double blind clinical trial study with 75 cases. these patients were ...

the case is 43 years old woman referred to emergency department of our hospital with quadriplegia and severe respiratory insufficiency due to c5-c6 injury after falling. she discharged from icu after fixation of the lesion and successful weaning. we evaluated electrical activity of diaphragm signal (edi), respiratory drive (p100) during one month period. we detected increase in level of electri...

spinal cord injury (sci) is a destructive condition that the cord can't send signals below the level of the injury. despite advances in the medical and surgical care of sci patients, no effective treatment exists for the neurological deficits of sci. cell therapy is a new approach for sci, and preclinical models demonstrate that cell transplantation can improve some secondary events throug...

The pathophysiology of acute spinal cord injury (SCI) involves primary and secondary mechanisms of injury. Secondary injury mechanisms include inflammation, oxidative stress. The secondary inflammation of spinal cord tissue after SCI was critical for the survival of motor neuron and functional recovery. Flaxseed is a rich source of lignan phytoestrogen, α-linolenic acid. Flaxseed has rema...

conclusions these results showed that the administration of sdf-1a increases the number of proliferating cells in the injured area in the spinal cord and improves functional recovery. results significant improvements in locomotor function were detected in the sdf-1 group compared with the sci and vehicle groups (p < 0.05). the results showed that sdf-1 treatment increased proliferative cells at...

Background and aims: One of the most common injuries around the world is the traumatic injury of the spine and spinal cord with unknown worldwide situation of traumatic spinal cord injury (TSCI) affecting on the effectiveness of preventive policy programs. In addition, because of possibility of making paralysis, the potential injury to the spine could be one of the most importa...

Background: Oligodendrocyte cell death is among the important features of spinal cord injury, which appears within 15 min and occurs intensely for 4 h after injury, in the rat spinal contusion model. Accordingly, the number of oligodendrocytes progressively reduced within 24 h after injury. Administration of oligodendrocyte-like cells (OLCs) into the lesion area is one of the approaches to coun...