that the left side was the seat of a tumefaction, the contours of which were those of an enlarged spleen. Smooth and firm, emerging from the left hypochondrium, and filling the flank, , its mesial border lay in a line from the anterior superior iliac spine to the epigastrium, and presented an edge with a double indentation resembling splenic notching, and splenic dulness was co-extensive with i...

a 55-year-old man presented with pain in the left flank for the last 8 months with history of significant weight loss. the pain was relieved on assuming a knee-chest position. on clinical examination the patient was afebrile with mild tenderness in the left hypochondrium. there was no icterus or lymphadenopathy. the spleen was palpable 6 cm below the costal margin and was firm and non-tender. t...

Malaria is endemic in the North of Brazil. However, Hyperreactive Malarious Splenomegaly (HMS) has been rarely described. Splenomegaly in HIV/Aids infection has a large differential diagnosis, but malaria is a cause of gross splenomegaly, regardless of the HIV status. In this paper, we report the case of a 50-year-old man, HIV positive, with massive splenomegaly and multiple malaria infections ...

Hyper-reactive malarial splenomegaly syndrome (HMSS) is a massive enlargement of the spleen due to an exaggerated immune response to repeated attacks of malaria. Tropical splenomegaly syndrome (TSS) is the most frequent cause of massive tropical splenomegaly in malarious areas [1-2]. It is seen more commonly among residents of endemic areas of malaria. It occurs mainly in tropical Africa, but a...

Objective. To study whether mean platelet volume (MPV) and splenomegaly could be used as subclinical inflammatory markers in children with familial Mediterranean fever (FMF) at the attack-free period. Patients and Methods. The study included ninety-seven children with FMF. MPV was carried out within 4 hours of blood sampling according to standard laboratory practice. Splenomegaly was determined...

The article by Levine et al.1 concerning abnormal liver chemistries and splenomegaly in intensively treated hemophiliacs left both observations unexplained. Although their literature search “revealed no reports of splenomegaly associated with hemophilia,” I would like to call attention to a 1966 report from our clinic on therapy of hemophilia with fraction I in which splenomegaly was observed a...