BACKGROUND Selective serotonin reuptake inhibitors (SSRIs) are typically used as antidepressants. Clinically significant SSRI-induced thyroid dysfunction is rare. CASE We report a case of hyperthyroidism induced by fluoxetine in a female patient with major depressive disorder. Her thyroid profiles indicated hyperthyroidism after a 10-week treatment with fluoxetine and were restored after disc...

The authors review the literature pertaining to selective serotonin reuptake inhibitor (SSRI)-induced apathy syndrome. A literature search of Medline and International Pharmaceutical Abstracts from 1970 to the present was performed for relevant articles. Twelve relevant case reports and one open-label treatment trial were identified. An amotivational, or apathy, syndrome has been reported in a ...

BACKGROUND Antidepressant prescribing continues to rise. Contributing factors are increased long-term prescribing and possibly the use of higher selective serotonin re-uptake inhibitor (SSRI) doses. AIM To review general practice patients prescribed the same antidepressant long-term (≥2 years) and evaluate prescribing and management pre and post-review. DESIGN AND SETTING Prospective obser...

BACKGROUND Antidepressant drugs such as selective serotonin re-uptake inhibitors (SSRIs) remediate negative biases in emotional processing in depressed patients in both behavioural and neural outcome measures. However, it is not clear if these effects occur before, or as a consequence of, changes in clinical state. METHOD In the present study, we investigated the effects of short-term SSRI tr...

Catalepsy occurs following high dopamine (DA) D2 blockade by typical antipsychotic drugs (APDs). We showed that a combination of a high dose of citalopram, a selective serotonin reuptake inhibitor (SSRI) and the selective 5-HT1A receptor antagonist WAY 100635 produces significant catalepsy in rats, similar to APDs. Here, we investigated the potential antipsychotic activity of lower doses of cit...

Major depressive disorder is a highly prevalent condition for which the treatment of fi rst resort is often a selective serotonin reuptake inhibitor (SSRI). There is a paucity of evidence about the long-term effects of SSRI use and unpleasant side effects of SSRIs are common. As a result, interest has increased in new and nonpharmacological treatments for depression. Various forms of electrical...

BACKGROUND Recent studies have shown that an increased bleeding tendency can be caused by Selective Serotonin Reuptake Inhibitors (SSRI) use. We aimed to investigate the occurrence and risk of blood transfusion in SSRI users compared to non-SSRI users in a cohort of patients admitted for hip-surgery. METHODS We conducted a retrospective cohort study of patients who underwent planned or emerge...

Selective serotonin re-uptake inhibitors (SSRIs) are one of the most commonly prescribed classes antidepressants used for treatment moderate to severe depressive disorder, personality disorders and various phobias. This class was created with improved margins safety. However, genetic polymorphism may be responsible high variability in patients’ responses treatment, ranging from failure delayed ...

BACKGROUND Treatment with selective serotonin reuptake inhibitors (SSRI) is one of the most common treatments for depression. It is however not clear whether or not there is an increased short-term suicide risk during initiation with SSRI. METHODS A register-based nationwide case-crossover study including 5,866 suicides, 1,698 women and 4,168 men, from the Death Register 2007-2010 in Sweden. ...

Sir: Akathisia may be defined as the subjective feeling of muscle discomfort usually manifesting as a result of treatment with antipsychotic medication. Moreover, the subjective experience is often associated with objective symptomatology such as restless leg movements, walking to and fro, and inability to sit in one place for an extended period of time. This undesirable side effect frequently ...