Here, we present the case of a 66-year-old female patient with acute myeloid leukemia and severe thrombocytopenia who came complaints painful per anal mass bleeding rectum for 1 year. The is known obesity, hypertension, diabetes mellitus has received three cycles chemotherapy decitabine. On examination, she was found to have fourth- degree hemorrhoids at 3, 7, 11 oclock positions edematous chan...

Binding configuration of a de novo stapled peptide on SARS-CoV-2 spike protein, as predicted by molecular simulation. Stapled residues enhance stability while interacting engage key amino acids the protein receptor-binding domain.

OBJECTIVE To compare the surgical outcomes of stapled and handsewn closures in loop ileostomies. METHODS The data of 225 patients requiring loop ileostomies from 2002 to 2007 were retrospectively evaluated. The patients underwent partial small-bowel resections and either handsewn or stapled anastomoses for the ileostomy closures. They were followed up postoperatively with routine surgical exa...

BACKGROUND Stapled hemorrhoidectomy was introduced as a new procedure for the surgical management of hemorrhoidal disease in 1993. We present a cohort longitudinal study performed in a community hospital setting where the short-term outcomes of stapled hemorrhoidectomy were compared with those of conventional hemorrhoidectomy. METHODS We compared 41 consecutive patients who underwent a conven...

Background: Hemorrhoids are one of the most common perianal diseases. They have several surgical and non-surgical treatment methods. Among surgical procedures, Stapler hemorrhoidopexy method has recently gained widespread acceptance. Hemorrhoidopexy with a circular stapler usually has a series of common and mild complications and a few rare and life-threatening complications such as rectal perf...

Stapled peptides have arisen as a new class of chemical probe and potential therapeutic agents for modulating protein-protein interactions. Here, we report the first two-component i,i+7 stapling methodology that makes use of two orthogonal, on-resin stapling reactions to incorporate linkers bearing a chiral centre into a p53-derived stapled peptide. Post-stapling modifications to the chain were...