We have studied the relationship between the Sendai virus (SeV) C proteins (a nested set of four proteins initiated at different start codons) and the interferon (IFN)-mediated antiviral response in IFN-competent cells in culture. SeV strains containing wild-type or various mutant C proteins were examined for their ability (i) to induce an antiviral state (i.e., to prevent the growth of vesicul...

BACKGROUND Saccadic eye velocity (SEV) has been shown to be a reliable neurophysiological tool for the assessment of gamma-aminobutyric acid GABA(A) receptor sensitivity. Administration of benzodiazepines targeting the GABA(A) receptor decreases SEV in healthy volunteers. Tiagabine is a new antiepileptic drug which acts via selective blockade of GABA reuptake. Therefore, we examined the effects...

A fixed flexion view (FFV) is useful for evaluating joint space when assessing the severity of osteoarthritis (OA) of the knee. We analyzed changes in joint space revealed by standing extended view (SEV) and FFV over a mean 4 years, to compare both views on their capacity to measure joint space width accurately at particular time points during follow-up.SEV and FFV images were acquired in patie...

We have used cDNA arrays to compare the activation of various cellular genes in response to infection with Sendai viruses (SeV) that contain specific mutations. Three groups of cellular genes activated by mutant SeV infection, but not by wild-type SeV, were identified in this way. While some of these genes are well known interferon (IFN)-stimulated genes, others, such as those for interleukin-6...

Broiler breast fillets are sometimes characterized grossly by white parallel striations in the direction of the muscle fibers, and the condition is referred to as white striping. Depending on the severity of white striping, fillets can be classified as normal (NORM), moderate (MOD), or severe (SEV). The present study was intended to determine the factors associated with the occurrence of white ...

Improving on a result of J.E. Littlewood, N. Levinson [3] showed that there are arbitrarily large t for which |ζ(1 + it)| ≥ e log2 t + O(1). (Throughout ζ(s) is the Riemann-zeta function, and logj denotes the j-th iterated logarithm, so that log1 n = logn and logj n = log(logj−1 n) for each j ≥ 2.) The best upper bound known is Vinogradov’s |ζ(1 + it)| (log t). Littlewood had shown that |ζ(1+it...

This paper contributes to the existing literature on dating currency crisis in three ways. First, we combine the Monte Carlo simulation with a modified Hill’s estimator method to obtain more robust results and efficiently deal with bias variance tradeoff in identifying extreme values. Second, we propose a systematic way to choose the reference country in building the Exchange Market Pressure in...

UNLABELLED The type I/III interferon (IFN) system has major roles in regulating viral pathogenesis, usually ameliorating pathogenesis by impairing virus replication through the antiviral actions of one or more IFN-induced proteins. Ifit2 is one such protein which can be induced by IFN or virus infection, and it is responsible for protecting mice from neuropathogenesis caused by vesicular stomat...