Department of Civil Engineering, The City College of the City University of New York, T-121 Steinman Hall, Convent Avenue at 140th Street, New York, NY 10031, U.S.A. Earthquake Engineering Research and Test Center, Guangzhou University, Guangzhou, Guangdong, China Department of Civil and Environmental Engineering, Rice University, Houston, TX 77005, U.S.A. Department of Mechanical Engineering a...

Regnase-1 is an RNase that directly cleaves mRNAs of inflammatory genes such as IL-6 and IL-12p40, and negatively regulates cellular inflammatory responses. Here, we report the structures of four domains of Regnase-1 from Mus musculus-the N-terminal domain (NTD), PilT N-terminus like (PIN) domain, zinc finger (ZF) domain and C-terminal domain (CTD). The PIN domain harbors the RNase catalytic ce...

OBJECTIVE To assess the magnitude and causes of over-diagnosis of prostatic intraepithelial neoplasia (PIN), as large differences are reported in the incidence of high-grade PIN, probably because of the variance in diagnosis and interpretation. PATIENTS AND METHODS Two urological pathologists prospectively reviewed 251 consecutive patients, received in consultation and who were diagnosed and ...

Plant development displays an exceptional plasticity and adaptability that involves the dynamic, asymmetric distribution of the phytohormone auxin. Polar auxin flow, which requires polarly localized transport facilitators of the PIN family, largely contributes to the establishment and maintenance of the auxin gradients. Functionally overlapping action of PIN proteins mediates multiple developme...

Pin structures on vector bundles are the natural generalization of Spin structures to the case of nonoriented bundles. Spin(n) is the central Z/2Z extension (or double cover) of SO(n) and Pin−(n) and Pin(n) are two different central extensions of O(n), although they are topologically the same. The obstruction to putting a Spin structure on a bundle ξ (= R → E → B) is w2(ξ) H(B;Z/2Z); for Pin it...

40 is a near branch, an analogous argument again shows that Pin(b) is q's lower-right quadrant. Thus, q is the closest connection between p, Pin(a) and Pin(b). Except for redundancies and pruning of sub-optimal trees, BB-SORT-C searches over all possible ways to construct a Steiner tree sequentially, such that each sink is added by a closest connection to some edge in the current tree. Thus, we...

PURPOSE The purpose of this study was to evaluate the accuracy of a 3.5-mm-diameter anterior cruciate ligament (ACL) tibial retrograde socket drilling pin versus a standard, 2.4-mm drill-tipped guide pin. A secondary purpose was to evaluate surgeon precision in identifying the true (anatomic) center of the ACL tibial footprint using arthroscopic visualization. METHODS Six matched pairs of cad...