Stem cells can be differentiated into cardiomyocytes by induction with 5-azacytidine (5-aza) but its carcinogenicity is of concern for future translational application. Alternatively, growth factors and hormones such as basic fibroblast factor (bFGF) hydrocortisone have been reported to act a therapeutic inducer differentiation. In this study, we aim investigate the ability bFGF in combination ...

Stress- and inflammation-induced growth differentiation factor-15 (GDF-15) is proposed as a biomarker for mortality disease progression in patients with atherosclerosis and/or cardiovascular (CVD). The development of atherosclerotic lesions depends, among other factors, on inflammatory processes, oxidative stress, impaired lipid homeostasis. As consequence, activation dysfunction endothelial ce...

Growth factor signaling is required for cellular differentiation, tissue morphogenesis, and tissue homeostasis. Misregulation of intracellular signal transduction can lead to developmental defects during embryogenesis or particular diseases in the adult. One family of growth factors important for these aspects is given by the Wnt proteins. In particular, Wnts have important functions in stem ce...

Introduction: The nerve fibers in central nervous system are surrounded by myelin sheet  which is formed by oligodendrocytes. Cell therapy based on oligodendrocytes and their precursors transplantation can hold a promising alternative treatment for myelin sheet repair in demyelinating diseases. Methods: Human Dental Pulp Stem Cells (hDPSCs) are noninvasive, autologous and easy available s...

Acute myocardial infarction and inherited cardiomyopathies, due to extensive loss of cardiomyocytes, may progress towards heart failure despite revascularization procedures and pharmacological treatments. Initial studies supported the concept that bone marrow cells may hold the promise of rebuilding the injured heart from its component elements, offering a valid alternative to the ultimate reso...

background: amniotic membrane derived stem cells (amscs) have considerable advantages to use in regenerative medicine and their anti- inflammatory effects, growth factor secretion and differentiation potential make them suitable candidates for stem cell therapy of nervous system. the developing and neonatal brain contains a spectrum of growth factors to direct development of endogenous and dono...

Growth factor signaling is required for cellular differentiation, tissue morphogenesis, and tissue homeostasis. Misregulation of intracellular signal transduction can lead to developmental defects during embryogenesis or particular diseases in the adult. One family of growth factors important for these aspects is given by the Wnt proteins. In particular, Wnts have important functions in stem ce...

Strategies of Schwann cell (SC) transplantation to regenerate the peripheral nerve injury involves many limitations. Stem cells can be used as alternative cell sources for differentiation into SCs. Given the high potential of neural crest-derived stem cells for the generation of multiple cell lineages, in this research, we considered whether olfactory ecto-mesenchymal stem cells (OE-MSCs) derive...

introduction  insulin-like growth factor i (igf-i) which is produced in abundance in the normal adult liver, is deeply involved in hepatocyte survival, growth, and differentiation during liver development. igf-i plays the roles via the receptor (igf-ir) signaling pathway. igf-ir unlike igf-i is expressed strongly in the developing liver, but much more weakly in adults. objective:  we hypothesiz...