BACKGROUND Depressive and anxiety disorders are common in general practice but not always treated adequately. Introducing stepped care might improve this. In this randomized trial we examined the effectiveness of such a stepped care model. METHODS The study population consisted of primary care attendees aged 18-65 years with minor or major DSM-IV depressive and/or anxiety disorders, recruited...

Stepped spillwayflows are characterised by significant free-surface aeration downstream of the inception point of air entrainment. The stepped design is advantageous for applications which require large energy dissipation and strong flow aeration. While the energy dissipation rate for embankment stepped spillways was studied previously, the optimum design for aeration and air–water mass transfe...

BACKGROUND The Disability in Strategies for Care (DISC) study was the first large randomised controlled trial to compare alternative treatment strategies in the acute treatment of migraine. With 835 patients in its intention-to-treat efficacy analysis, DISC compared a stratified care strategy, where initial therapy was based on clinical need as determined by the Migraine Disability Assessment S...

Introduction: The carbonaceous chondrites are among the most primitive solid objects in the solar system and plausibly represent building blocks of the terrestrial planets, moons and asteroids [1,2]. Although they are generally less differentiated and metamorphosed than other meteorite groups, the car-bonaceous chondrites are compositionally and textur-ally diverse, in part reflecting processes...

Submitted as: van der Aa HPA, van Rens GHMB, Bosmans JE, Comijs HC, van Nispen RMA. Economic evaluation of stepped care for depression and anxiety in visually impaired older adults: multicentre randomised controlled trial 168 169 9 Chapter 9 Economic evaluation of stepped care: RCT

AIM To compare postoperative keratometric corneal refractive changes after phacoemulsification surgery between pre-incision and single stepped clear corneal incision techniques. PATIENTS AND METHODS This prospective clinical study included 40 eyes of 40 patients who underwent clear corneal cataract surgery. Twenty eyes were operated using pre-incision technique (Group A), and 20 eyes using si...

OBJECTIVE Both methadone and buprenorphine are effective therapy for heroin dependence. Efficacy is best documented for methadone maintenance therapy, but safety concerns limit its use. Buprenorphine offers lower overdose risk and improved access, but efficacy may be lower. The authors compared adaptive, buprenorphine-based stepped care to optimal methadone maintenance treatment. METHOD This ...

For the first time, one-pot solution-phase selective-etching to create cuboctahedral Cu2O crystals enclosed by both stepped {111} surfaces and smooth {100} surfaces has been demonstrated. Investigation of photocatalytic performances indicates that the stepped cuboctahedral Cu2O crystals have higher photocatalytic activities than those of the common smooth ones.

Population-level laterality is generally considered to reflect functional brain specialization. Consequently, the strength of population-level laterality in manipulatory tasks is predicted to positively correlate with task complexity. This relationship has not been investigated in tool manufacture. Here, we report the correlation between strength of laterality and design complexity in the manuf...