Abstract Radiation induced pseudoprogression (PsP) of brain tumors is defined radiologically as new or enlarging areas non-tumor magnetic resonance imaging (MRI) contrast enhancement developing within the initial 3-6 months after completing radiation. Distinguishing PsP from genuine tumor progression utmost importance in deciding clinical course a patient. Although it typically diagnosed radiol...

Mitotane (o,p'DDD) is established in the adjuvant and advanced-stage treatment of adrenocortical carcinoma and counteracts both tumor growth and tumor-related steroid production. Both the adrenal glands and the gonads are steroidogenically active organs and share a common embryogenic origin. Here, we describe the effects of mitotane in two patients with metastatic Leydig cell tumor (LCT) of the...

Events preceding the cortisol inhibition of uridine utiliza tion by corticoid-sensitive P1798 lymphocytes have been investigated. When tumor cells were incubated with I @M cortisol for IS mm and then washed free of steroid and reincubated in the absence of hormone, the expected decrease of uridine uptake failed to appear 1.5 hr later. In Contrast, the removal of cortisol after 30 or 60 mm did n...

Steroid alkaloids have been suggested as potential anticancer compounds. However, the underlying mechanisms of how steroid alkaloids inhibit the tumor growth are largely unknown. Here, we reported that solanine, a substance of steroid alkaloids, has a positive effect on the inhibition of pancreatic cancer cell growth in vitro and in vivo. In pancreatic cancer cells and nu/nu nude mice model, we...

Events preceding the cortisol inhibition of uridine utiliza tion by corticoid-sensitive P1798 lymphocytes have been investigated. When tumor cells were incubated with I @M cortisol for IS mm and then washed free of steroid and reincubated in the absence of hormone, the expected decrease of uridine uptake failed to appear 1.5 hr later. In Contrast, the removal of cortisol after 30 or 60 mm did n...

Steroid cell tumors, not otherwise specified, are infrequently encountered ovarian neoplasms, which constitute <0.1% of all ovarian tumors. Most of these tumors are unilateral, and almost one-third of all cases are reportedly malignant. However, because most of these tumors are diagnosed in the early stage, and do not recur or metastasize, little is known about their response to therapies such ...

Steroid-refractory graft-versus-host disease is a life-threatening complication after allogeneic stem cell transplantation. Evidence is accumulating that steroid-refractory graft-versus-host disease is associated with endothelial distress. Endothelial cell homeostasis is regulated by nitric oxide, and serum nitrates are derived from nitric oxide synthase activity or dietary sources. In this ret...

Central nervous system infiltration by acute leukemia is a poor prognosis variable, and conventional cytology the gold standard for its diagnosis; technique highly specific but not sensitive. To improve diagnosis, flow cytometry has been used in different studies, showing greater sensitivity detection of leukemic cells. This study aimed to evaluate presence tumor cells flowcytometry cytology, c...