نتایج جستجو برای: steroid resistant
تعداد نتایج: 235531 فیلتر نتایج به سال:
BACKGROUND There is evidence to indicate that peripheral glucocorticoid receptor (GR) function is reduced in major depression, and a possible molecular explanation for this is the impact of raised pro-inflammatory cytokines. The topical steroid vasoconstriction assay provides a convenient probe of peripheral GR function. The present study sought to assess the sensitivity of peripheral GRs in an...
Mesenchymal stromal cells (MSCs) have been reported to have immunomodulatory effects and ameliorate severe graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (SCT). We have conducted a pilot study using human MSCs for the treatment of steroid-resistant GVHD. Between January 2006 and December 2010, 10 patients (7 males and 3 females) with a median age of 37.9 years (rang...
Treatment of nephrotic syndrome due to minimal change disease and focal segmental glomerulosclerosis remains a challenge since steroid dependence, steroid resistance and a relapsing disease course exhibits a high cumulative steroid dosage. The necessity of using alternative steroid-sparing immunosuppressive agents with potential toxic side effects also restricts their long-term use. Rituximab, ...
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