Tendon never restores the complete biological and mechanical properties after healing. Bone marrow and recently adipose tissue have been used as the sources of mesenchymal stem cells, which have been proven to enhance tendon healing. Stromal vascular fraction (SVF), derived from adipose tissue by an enzymatic digestion, represents an alternative source of multipotent cells, which undergo differ...

Developing in vitro models that recapitulate the vivo organization of living cells a 3D microenvironment is one current challenges field tissue engineering. In particular for anisotropic tissues where alignment precursor required them to create functional structures. Herein, new method proposed allows aligning direction uniform magnetic both individual (muscle, stromal, and stem cells) or spher...

One of the most important tasks biotechnology and regenerative medicine is to achieve long-term expansion hematopoietic stem cells. promising approaches optimizing cultures cells creation a microenvironment in form feeder stromal layers, which allows for reproduction combination soluble cytokines growth factors necessary hematopoiesis promotes an increase their proliferation [1,2].

IgA vasculitis (IgAV) is a systemic, immune complex–mediated, small-vessel leukocytoclastic vasculitis. In the cutaneous tissue, it characterized by nonthrombocytopenic palpable purpura. Increasing evidence suggests importance of host immunity in its contribution to IgAV. However, molecular mechanisms tissue damage IgAV remain largely unknown. We performed single-cell RNA sequencing on biopsied...

Background: Breast cancer is formed of a neoplastic component (epithelial) and a non-neoplastic component (stroma). Stromal- stromal and tumor- stromal interactions have been shown in the regulation of cancer cell growth, metastatic capacity and outcome of treatment. Tumor-associated macrophages (TAMs) are a component of tumor stroma reactionsand are considered as an important ...

In prostate tumors, both the epithelial and stromal mesenchyme compartments show gene expression changes from their respective normal counterpart. In fact, there are more such changes in the stroma than the epithelium. These include down-regulated expression of genes involved in smooth muscle cell differentiation and those differentially expressed between prostate and bladder, i.e., organ-restr...

Breast cancer tissues include carcinoma cells and stromal cells, intra-tumoral stroma that consists of different types cells. For this point, cell-cell interaction communication have a potential role in progression. Mono-cell culture is used for treatment approaches. However, can not be evaluated on mono-culture So, co-culture models provide low-cost screening to determine cell proliferation dr...

purpose : to assess and to compare stromal and endothelial changes at the cellular level in patients who had photorefractive keratectomy (prk) and laser in situ keratomileusis (lasik) using in vivo confocal microscopy methods : in this semiexperimental study, 32 eyes of 16 patients (4 males and 12 females) with low to moderate myopia [-1.00 to -4.50 diopters (d)] or low to moderate myopic astig...