Two anthocyanins, cyanidin-3-alpha-O-rhamnoside (C3R) and pelargonidin-3-alpha-O-rhamnoside (P3R), and quercitrin (quercetin-3-alpha-O-rhamnoside), were isolated from acerola (Malpighia emarginata DC.) fruit. These polyphenols were evaluated based on the functional properties associated with diabetes mellitus or its complications, that is, on the radical scavenging activity and the inhibitory e...

Acidification of the endosomal pathway is important for ligand and receptor sorting, toxin activation, and protein degradation by lysosomal acid hydrolases. Fluorescent probes and imaging methods were developed to measure pH to better than 0.2 U accuracy in individual endocytic vesicles in Swiss 3T3 fibroblasts. Endosomes were pulse labeled with transferrin (Tf), alpha 2-macroglobulin (alpha 2M...

We propose to obtain information on the spin-isospin dependence of $\mathrm{\ensuremath{\Xi}}N$ interaction through energy levels $\mathrm{\ensuremath{\Xi}}N\ensuremath{\alpha}$ and $\mathrm{\ensuremath{\Xi}}N\ensuremath{\alpha}\ensuremath{\alpha}$ systems, with $\ensuremath{\alpha}$ being a spectator attract pair without changing its structure. By using Gaussian expansion method state-of-the-a...

Chronic gastrointestinal diseases such as ulcerative colitis and Crohn's disease are characterized by severe diarrhea. Mucosal biopsies of these patients show enhanced levels of cytokines, secreted by infiltrated inflammatory cells. In this study, we investigated the effect of the cytokine tumor necrosis factor-alpha (TNF-alpha) on ion secretion in human intestinal epithelial cells. The convent...

The diverse functions of thyroid hormones are thought to be mediated by two nuclear receptors, T3R alpha1 and T3R beta, encoded by the genes T3R alpha and T3R beta respectively. The T3R alpha gene also produces a non-ligand-binding protein T3R alpha2. The in vivo functions of these receptors are still unclear. We describe here the homozygous inactivation of the T3R alpha gene which abrogates th...

Lewy bodies and Lewy neurites are the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies. They are made of abnormal filamentous assemblies of unknown composition. We show here that Lewy bodies and Lewy neurites from Parkinson's disease and dementia with Lewy bodies are stained strongly by antibodies directed against amino-terminal and carboxyl-termin...

the concept of algebraic hyperstructures introduced by marty as a generalization of ordinary algebraic structures. in an ordinary algebraic structure, the composition of two elements is an element, while in an algebraic hyperstructure, the composition of two elements is a set. the concept of ?-semihyperrings is a generalization of semirings, a generalization of semihyper rings and a generalizat...

Let $\mathscr {R}$ be an $\mathrm {NIP}$ expansion of $(\mathbb {R},<,+)$ by closed subsets $\mathbb {R}^n$ and continuous functions $f : \mathbb {R}^m \to {R}^n$. Then is generically locally o-minimal. This follows from a more general theorem on expansions compact groups, which itself result quotients definable sets in $\aleph _1$-saturated structures equivalence relations are both externally ...