J chain is associated with pentameric IgM and dimeric IgA via disulfide bonds involving the penultimate cysteine residue in the secretory tailpiece of the mu or the alpha heavy chain. We have investigated the structural basis for incorporation of J chain by analyzing several IgM mutants, IgA mutants and IgG/IgM hybrid molecules. IgM mutants with the mu secretory tailpiece replaced by the alpha ...

The genome of influenza A virus is comprised of eight viral RNA (vRNA) segments. Although the products of all eight vRNA segments must be present for viral replication, little is known about the mechanism(s) responsible for incorporation of these segments into virions. Two models have been proposed for the generation of infectious virions containing eight vRNA segments. The random-incorporation...

wood resources, non-wood plants and recycled papers are the common raw materials of papermaking. shortage of raw materials, is a challenging problem in developing pulp and paper industry. in this study, cladophora green algae was used as a new source of cellulosic fiberfor pulping and papermaking.. cladophora algae was cooked with cold soda method and then was mixed with nssc pulp at 10,20 and ...

land use is often referred as the basis for urban planning. perhaps the main reason is that the discussion of fundamental related to urban planning objectives has play the first role in the land use studies. basic topics such as proper location, optimal allocation, diversification, functionality and … which are in direct contact with comfort goals, are the last objectives of urban planners and ...

Fe3O4-Au hybrid nanoparticles (HNPs) have shown increasing potential for biomedical applications such as image guided stimuli responsive drug delivery. Incorporation of the unique properties of HNPs into thermally responsive scaffolds holds great potential for future biomedical applications. Here we successfully fabricated smart scaffolds based on thermo-responsive poly(N-isopropylacrylamide) (...

This research aims to produce non-structural concrete with mixed recycled aggregates (MRA) in upscaled applications with low-cement content. Four slabs were executed with concrete made with different ratios of coarse MRA (0%, 20%, 40% and 100%), using the mix design, the mixing procedures and the facilities from a nearby concrete production plant. The analysis of the long-term compressive and s...