T he progress of medicine is often driven by the development of new ideas in the experimental laboratory and their subsequent application to clinical practice. Sometimes the clinical usefulness of these ideas may not be evident when they are first formulated but becomes apparent after a period of time. The concept of postischemic myocardial dysfunction, or "myocardial stunning,"' is a classic e...

III " Everything is possible but the impossible – just do it " 131 I is widely used clinically in the treatment of Graves´disease and differentiated thyroid cancer. However, cellular and molecular effects of 131 I irradiation in relation to absorbed dose are poorly documented. For instance, it is unknown what absorbed doses give rise to acute or delayed lethality, DNA damage that is fully resto...

Introduction: Cardiovascular disease (CVD) has been well documented as the leading cause of death in the general population worldwide. Physical activity is a modifiable factor in the development and progression of CVD reducing its incidence by 42-44% and reducing mortality and hospital admissions. The presence of chronic kidney disease (CKD), and the recurrence of cumulative circulatory stress ...

The present experiment was conducted to provide a large-scale objective comparison of pork LM tenderness and other meat quality traits among packing plants that differ in stunning method and carcass chilling rate. For each of 2 replicates, pigs were sourced from a single barn of a commercial finishing operation that fed pigs from a single terminal crossbred line. On each day, 3 trucks were load...

This study was undertaken to elucidate whether cal-adrenoceptor activity is beneficial to contractile dysfunction during reperfusion after a brief period of ischemia (stunned myocardium) in 54 open-chest dogs. Contractile dysfunction assessed by fractional shortening (FS) was observed 3 hours after the onset of reperfusion following 15 minutes of complete occlusion of the left anterior descendi...

Among the numerous mechanisms proposed for myocardial stunning, three appear to be more plausible: 1) generation of oxygen radicals, 2) calcium overload, and 3) excitation-contraction uncoupling. First, the evidence for a pathogenetic role of oxygen-derived free radicals in myocardial stunning is overwhelming. In the setting of a single 15-minute coronary occlusion, mitigation of stunning by an...

A total of 1020 crossbreed rabbits were individually examined to evaluate their welfare at electric stunning and slaughtering in a commercial abattoir. Stunning (position of electrodes and repetition of current applications) and sticking (position, length and depth of the cut) procedures were checked. Rabbits were behaviourally monitored from current application to death. The stunning system wa...