BACKGROUND Leiomyosarcoma is a rare malignant mesenchymal tumor that represents 5-7 % of all soft tissue sarcomas. The occurrence of this tumor in the salivary glands is exceptional. Only five cases are reported in the submandibular gland. CASE PRESENTATION A 65-year-old white Moroccan woman presented with a history of progressive right submandibular swelling which had grown over a period of ...

INTRODUCTION Sialolithiasis is the most common cause of salivary gland disease and about 80% to 90% of stones occur in the submandibular gland (SMG). Among them, 40% of the SMG stones are located in the distal submandibular duct near the punctum, and they are removed through the intraoral approach. The other 60% of the SMG stones are located in the proximal submandibular duct or in the submandi...

BACKGROUND/AIM The submandibular gland is one of the three major salivary glands, producing a mixed secretion; this saliva is hypotonic compared to plasma. It also secretes glucose, but the mechanisms responsible for this process are poorly understood. Our study addressed the question whether glucose transporters are expressed and how are they localized within specific rodent submandibular cell...

OBJECTIVES brain-derived neurotrophic factor (BDNF), which is produced in rat submandibular gland, is one of the most abundant neurotrophins in the central nervous system. It is generally accepted that occlusal disharmony causes stress. The purpose of the present study was to investigate whether occlusal disharmony-induced chronic stress affects BDNF levels and morphology in rat submandibular g...

Experimental animal models of diabetes induced either by alloxan or streptozotocin have been used to study aspects of the pathophysiology of this disease. The purpose of this study was to examine the metabolism of glycogen in the submandibular and parotid salivary glands of diabetic rats. Diabetes was induced by an intraperitoneal injection of streptozotocin. Eight weeks after the induction of ...

OBJECTIVE To assess the diagnostic accuracy of fine-needle aspiration (FNA) of the parotid and submandibular glands. STUDY DESIGN Case series with chart review. SETTING Tertiary referral academic center. SUBJECTS AND METHODS Retrospective analysis was performed for all parotid and submandibular gland FNAs from a single center from 2001 to 2014. There were 1283 FNAs performed for 1076 pati...

PURPOSE We aimed to assess the problem solving capability of magnetic resonance sialography (MR sialography), a noninvasive method for imaging submandibular gland ducts and determining duct-related pathologies, by comparing diseased and healthy cases. MATERIALS AND METHODS We conducted radiological assessment on a total of 60 submandibular glands (mean age 44.7) in 20 cases and 10 volunteers....

Ectopic thyroid can be encountered anywhere between the base of tongue and pretracheal region. The most common form is euthyroid neck mass. Herein, we aimed to present the findings of a female case with ectopic thyroid tissue localized in the left submandibular region. A 44-year-old female patient, who underwent bilateral subtotal thyroidectomy four years ago with the diagnosis of multinodular ...

BACKGROUND : Either excision of the submandibular gland during neck dissection or having the submandibular gland in radiation field can result in xerostomia, leading to reduced quality of life. The purpose of this study was to evaluate the prevalence of metastasis to the submandibular gland and to identify potential risk factors leading to the presence of metastases into the gland. PATIENTS A...

Zhang Y, Catalán MA, Melvin JE. TRPV4 activation in mouse submandibular gland modulates Ca influx and salivation. Am J Physiol Gastrointest Liver Physiol 303: G1365–G1372, 2012. First published October 18, 2012; doi:10.1152/ajpgi.00366.2012.—Transient receptor potential vanilloid subtype 4 (TRPV4) is a ligand-gated nonselective cation channel that participates in the transduction of mechanical ...