Malignant melanoma is associated with poor clinical prognosis; however, novel molecular and immune therapies are now improving patient outcomes. Almost 50% of melanomas harbor targetable activating mutations of BRAF that promote RAS-RAF-MEK-ERK pathway activation and melanoma proliferation. Recent evidence also indicates that melanomas bearing mutant BRAF may also have altered immune responses,...

We carried out a retrospective survey of 25 years of clinical experience with the use of clonazepam as a vestibular and tinnitus suppressant in the pharmacological treatment of vestibular or cochleovestibular disorders due to different causes. We reviewed the medical records of 3,357 outpatients treated with a 0.5 or 1.0-mg daily dosage of oral clonazepam during 60-180 days. Complete or substan...

<em>Until now, after the pandemic began to subside and face-to-face learning mode is held, smartphones have become a supporting object in almost every aspect of students' daily activities, because they are considered practical efficient. Researchers want develop android-based interactive media on volleyball material that can help PJOK teachers delivering materials interesting easy underst...

Analysis of seepage and stability is considered as an important case in designing which today, withadvanced numeric software acceptable results will be obtained before and after Construction. In thepresent study, the behavior of earth dam against effective factors was investigated by softwareAnsys12. The studied dam is Maroun soil dam, which is located in 19Km north of Behbehan andconstructed o...

Concepts of Human Computer Interaction have crossed disciplinary boundaries allowing the discovery of underlying stakeholder affordances to emerge during the design research phase of system design. For the current scenario, middle school mathematics teachers as data-driven decision makers are inundated with diagnostic and assessment data, resulting in data deluge. The situation is unlikely to s...

This study focuses on the effects of news and advertising expenditures on corporate reputation. Both advertisement expenditures and the tone (or tenor) of business news exert a positive influence on corporate reputation. In addition, advertising expenditures were found to magnify the effects of the tone of the news. In particular, moderately educated customers are susceptible to the tone of the...

Severe sepsis with multiple organ dysfunction remains the most common cause of death for patients treated in intensive care units. As there is no specific treatment for severe sepsis, current management consists of antibiotics, source control and the use of supportive therapies to sustain life while waiting for the adverse effects of sepsis-induced organ dysfunction to subside. Despite the cent...

WE PROPOSE A NOVEL AUTOMATED ALGORITHM FOR CLASSIFYING DIAGNOSTIC CATEGORIES OF OTITIS MEDIA: acute otitis media, otitis media with effusion, and no effusion. Acute otitis media represents a bacterial superinfection of the middle ear fluid, while otitis media with effusion represents a sterile effusion that tends to subside spontaneously. Diagnosing children with acute otitis media is difficult...

Plants require water for growth and development, but excessive water negatively affects their productivity and viability. Flash floods occasionally result in complete submergence of plants in agricultural and natural ecosystems. When immersed in water, plants encounter multiple stresses including low oxygen, low light, nutrient deficiency, and high risk of infection. As floodwaters subside, sub...

Rifabutin-associated uveitis has been recognized as a dosage-dependent side effect. Previous studies have reported that clarithromycin or fluconazole may elevate concentrations of rifabutin through inhibition of metabolism through the cytochrome P-450 pathway. Nelfinavir is a protease inhibitor widely used in the treatment of human immunodeficiency virus (HIV) infection. The interactions betwee...