Small-molecule fluorescent reporters of disease states are highly sought after, yet they remain elusive. Anthranilic acids are extremely sensitive environmental probes, and hold promise as general but selective agents for cancer-cell detection if they can be equipped with the appropriate targeting groups. The optical properties of a small library of N-isopropyl invariant anthranilic acids were ...

BACKGROUND A system was developed for the simultaneous measurement in urine of free catecholamines (i.e., dopamine, norepinephrine, epinephrine) and creatinine (i.e., an indicator of urine output and volume). This method was based on the use of tandem affinity/ion-pair HPLC and flow injection analysis. METHODS The free catecholamines were extracted directly from urine by using an on-line phen...

The coupling reaction of phenylboronic acid with 4-silyl-bromobenzenes incorporating an ionic liquid support or its neutral analogue at 80 °C in DMF/H2O in the presence of Pd(PPh3)4 and Na2CO3 takes place much faster and more efficiently under microwave irradiation than under traditional heating. It is an attractive method to carry out the generally slow Suzuki–Miyaura reactions under microwave...

A simple strategy is provided to construct novel supramolecular hydrogels with both self-healing and shape memory properties. Starting from achieving self-healable hydrogel based on the dynamic interactions of phenylboronic acid modified sodium alginate (Alg-PBA) and poly(vinyl alcohol) (PVA), further formation of a complex of alginate with Ca(2+) renders this hydrogel with the capability of sh...

Stable and monodisperse phenylboronic acid-functionalized nanoparticles (PBA-NPs) were fabricated using 3-((acrylamido)methyl)phenylboronic acid homopolymer (PBAH) via solvent displacement technique. The effect of operating parameters, including stirring time, initial polymer concentration and the proportion of methanol on the self-assembly process were systematically investigated. The diameter...

Research into polymers with glucose-sensitivity in physiological conditions has expanded recently due to their therapeutic potential in diabetes. Herein, to explore the glucose-responsive properties of a new polymer under physiological conditions, we synthesized an amphiphilic block glycopolymer based on phenylboronic acid and a carbohydrate, which was named poly(d-gluconamidoethyl methacrylate...