Sañudo-Peña, M. Clara and J. Michael Walker. Role of the cannabinoid receptor binding in this area (Herkenham et al. subthalamic nucleus in cannabinoid actions in the substantia nigra 1991a). of the rat. J. Neurophysiol. 77: 1635–1638, 1997. The effect of Cannabinoids inhibit neurotransmission through activacannabinoids on the excitatory input to the substantia nigra reticution of K channels an...

  Abstract   Introduction: It is demonstrated that the degree of clinical improvement in   Parkinson's disease (PD) achieved by deep brain stimulation (DBS) is largely dependent   on the accuracy of lead placement. In addition, individual variability in the   situation of subthalamic nucleus (STN) is responsible for spatial inter-individual   fluctuations of the real patient's target.   Objecti...

A BSTRACT Background Increased neuronal activity in the subthalamic nucleus and the pars interna of the globus pallidus is thought to account for motor dysfunction in patients with Parkinson’s disease. Although creating lesions in these structures improves motor function in monkeys with induced parkinsonism and patients with Parkinson’s disease, such lesions are associated with neurologic defic...

Purpose of review The clinical effectiveness and limitations of subthalamic nucleus deep brain stimulation for Parkinson’s disease are summarized and recent developments concerning alternative brain targets for deep brain stimulation or restorative surgical therapies are discussed. Recent findings In a controlled study subthalamic nucleus deep brain stimulation was superior to best medical mana...

Background Oxytocin may be a possible treatment for multiple neuropsychiatric disorders, including cocaine addiction. Little is known about the site-specific effects of oxytocin on various drug addiction-related brain regions. Furthermore, sexually dimorphic effects of oxytocin on neural function in the addiction circuit have not been established. Here, we studied Fos expression following cocai...