The accumulation of lactic acid in tumor tissue (15) suggests an inadequacy in the oxidative mechanism. A deficiency of one of the components of the oxidative mechanism, cytochrome c, was demonstrated in the first paper of this series (6). The present article reports the decreased activities of succinic dehydrogenase and of cytochrome oxidase in tumor tissues. These enzymes together with cytoch...

In this work was synthesized an amino-steroid derivative (4); the route involved preparation of dihydrotestosterone-hemisuccinate (2) by the esterification of dihydrotestosterone (1) using succinic anhydride and pyridine (method A) or using succinic acid and 1,3 dicyclohexylcarbodiimide in presence of p-toluensulfonic acid (method B). After 2 was coupled to 4-hidroxy benzoic acid using 1,3 dicy...

Succinic acid-producing Anaerobiospirillum succiniciproducens was anaerobically grown in glucose-fed continuous cultures using glucose as a carbon source, and the metabolic flexibility of A. succiniciproducens in response to varying glucose concentrations and dilution rates was examined. Both succinic acid (SA) and acetic acid (AA) formation was growth-associated, and their growth-rate-related ...

A homologous series of cationic gas-phase clusters of dicarboxylic acids (oxalic acid, malonic acid, succinic acid, glutaric acid, and adipic acid) generated via electrospray ionization (ESI) are investigated using collision-induced dissociation (CID). Singly charged cationic clusters with the composition (Na(+))(2n+1)(dicarboxylate(2-))(n), where n = 1-5, are observed as major gas-phase specie...

in fermented products containing bifidobacteria, factors such as organic acid concentration and b-galactosidase activity are important in the development of flavor and texture of final products. both the process conditions and medium components have significant effects on fluctuation of such factors. the effects of whey permeate powder and yeast extract concentrations, as nitrogen sources was i...

The effects of chloroacetaldehyde (CAA) and methylene blue, both alone and together, on mitochondrial metabolism, hepatic glutathione content, and bile flow were investigated in rats. Oxidation of [1-14C]palmitic acid, [1-14C]octanoic acid, and [1,4-14C]succinic acid allowed for the differentiation between carnitine-dependent long-chain fatty acid metabolism, medium chain fatty acid oxidation, ...