Neutrophils metabolize arachidonic acid through the liposygenase pathway to 5-hydroxy-6,8,11,14-eicosatetrenoic acid (5-HETE) and 5,12-dihydroxy-6,8,10,14-eicosatraenoic acid (5,12 diHETE). 5-HETE and 5,12diHETE are potent chemotactic agents and are thought to have important roles in the inflammatory response. In this study we demonstrate the sulfasalazine, at concentrations found in the stool ...

A 57-year-old male with a history of alcoholism presented to the emergency room with abdominal pain, jaundice, transaminitis, and hyperbilirubinemia. Due to the history of alcoholism, it was initially presumed that the patient had alcoholic hepatitis but further investigation revealed that he was recently started on sulfasalazine for the treatment of rheumatoid arthritis. Upon cessation of the ...

Background and objectives: Pelargonium graveolens L'Hér. is an essential oil bearing plant used in traditional medicine of Iran for the treatment of inflammatory disease and pain, anxiety, sadness and also for the relief of gastrointestinal symptoms. Its pharmaceutical product is presently used in Iran for the treatment of depression disorders. Since colitis is a brain...

The title compound, 5-[4-[(2-pyridylideneamino)sulfonyl]phenyldiazenyl]salicylic acid, C(18)H(14)N(4)O(5)S, crystallizes as the imide tautomer in the monoclinic space group P2(1)/c. In addition to an intramolecular O-H.O hydrogen bond, intermolecular O-H.O interactions link adjacent molecules into helices, which are connected by pairwise N-H.N interactions into two-dimensional hydrogen-bonded l...

Despite the availability of several new agents for the treatment of rheumatoid arthritis (RA), sulfasalazine remains the mainstay because of both cost and experience with its use. Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and several polymorphisms have been described in the MTHFR gene. Of these, the 677C>T and 1298A>C polymorphisms have been associated with al...

Inflammatory bowel disease (IBD) is a chronic relapsing and remitting inflammatory disorder of the small intestine colon. IBD includes ulcerative colitis (UC) Crohn’s (CD), it main reason for expansion colon cancer, referred to as colitis-associated cancer (CAC). Oral colon-targeted microsphere based drug delivery system containing sulfasalazine was prepared, optimized characterized. The micros...