Accurate prediction of promoters is fundamental for understanding gene expression patterns, cell specificity and development. In the studies of conserved features of regulatory regions of orthologous genes, it was observed that major promoter functional components such as transcription start points, TATA-boxes and regulatory motifs, are significantly more conservative than the sequences around ...

The metabolism of sodium 3 alpha,7 beta-dihydroxy-5 beta-cholane-24-sulfonate and sodium 3 alpha,7 beta-dihydroxy-24-nor-5 beta-cholane-23-sulfonate was studied in hamsters. In bile fistula animals these sulfonate analogs of ursodeoxycholic acid were absorbed mainly from the terminal ileum and secreted rapidly into the bile without biotransformation or conjugation. After oral administration, th...

Aldehyde dextran sulfonate (ADS), a modified oligosaccharide polymer, was used to prepare a new matrix structure for affinity biosensors. The principal difference between the ADS matrix and similar structures developed previously results from presence of two active functional groups in the matrix, namely, aldehyde and sulfonate. These groups perform two different functions in the matrix. The al...

Crystalline polymorphism of organic semiconductors is among the critical factors in determining the structure and properties of the resultant organic electronic devices. Herein we report for the first time a solvent-type-dependent polymorphism of a long fused-ring organic semiconductor and its crucial effects on charge transport. A new polymorph of 5,11-bis(triethylsilylethynyl)anthradithiophen...

[1] Error covariances and vertical resolutions are reported for Tropospheric Emission Spectrometer (TES) nadir-view retrievals of surface temperature, atmospheric temperature, H2O, O3, CO, and CH4. These error covariances are computed as a result of selecting spectral windows that maximize the information content of simulated, TES nadir-view atmospheric retrievals of four regions representative...

To act effectively in a complicated, uncertain world, people often rely on task-sets (TSs) that define action policies over a range of stimuli. Effectively selecting amongst TSs requires assessing their individual utility given the current world state. However, the world state is, in general, latent, stochastic, and time-varying, making TS selection a difficult inference for the agent. An open ...

INTRODUCTION In clinical settings, neuropsychological test performance is traditionally evaluated with total summary scores (TSS). However, recent studies demonstrated that indices of intraindividual variability (IIV) yielded unique information complementing TSS. This 18-month longitudinal study sought to determine whether IIV indices derived from a multitrial list-learning test (the Rey Audito...

This study determined total suspended sediment (TSS) at six stream crossings that represented a range of site conditions and forest operations in the Piedmont of North Carolina. Two wood and three steel bridgemats and one culvert were installed to cross the streams. The road classes for the crossings included four temporary skid trails and two permanent forest haul roads. Baseflow and stormflow...

It has been reported that exogenously introduced micro- RNA (exo-miRNA) competes with endogenously expressed miRNAs (endo-miRNAs) in human cells, resulting in a detectable upregulation of mRNAs with endo-miRNA target sites (TSs). However, the detailed mechanisms of the competition between exo- and endo-miRNAs remain uninvestigated. In this study, using 74 microarrays that monitored the whole-tr...

We performed sequential and quantitative vaginal cultures obtained from 8 women within 4 days to 3 years (average, 15.8 months) after their recovery from classic menstrual toxic shock syndrome (TSS) and from 11 healthy women who served as age-matched controls. Apart from tampon use, which was significantly less frequent in TSS women after their acute illness, no demographic differences were obs...