of cases of smallpox, treated by me during the period 13th October, 1940 to 15th March, 1941, in the recent epidemic in Bezwada town. I do not claim any originality for the treatment. The chief interest of the investigation is that it combines the two remedial agents that have recently come to be recognized as of definite therapeutic value in this disease; namely, liver extract and the sulphona...

The binding of substrates and inhibitors to dihydrofolate reductase was studied by steady-state kinetics and high-field 1H-n.m.r. spectroscopy. A series of 5-substituted 2,4-diaminopyrimidines were examined and were found to be 'tightly binding' inhibitors of the enzyme (Ki less than 10(-9) M). Studies on the binding of 4-substituted benzenesulphonamides and benzenesulphonic acids also establis...

Drug eruptions are probably the most frequent of all manifestations of drug sensitivity. They occur in about 2% of treatment courses and are commoner in women, the elderly and in patients with the acquired immunodeficiency syndrome (AIDS), especially from sulphonamides such as in co-trimoxazole1. Drugs most often incriminated are listed in Table 1. The prevalence of a history of penicillin alle...

The long-acting "sulfamoxole" has the advantage that fewer doses are required. Sulphonamides alone are not particularly successful in non-gonococcal urethritis (NGU). The best results have been obtained with the tetracyclines (with and without oleandomycin), and success rates of 81 -5 to 85 4 per cent. may be obtained (Willcox, 1958). A number of authors (e.g. Lyall, 1953; Jelinek, 1957; Prebbl...

Introduction TRACHOMA has a world-wide distribution. It has been estimated that over 400 million people throughout the world are infected with trachoma. Trachoma and associated infections present a major public health problem in India, particularly in the northern and north-western states. Its effects frequently create serious economic problems; not infrequently it produces total blindness. Des...