Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft copolymer abbreviated SOL) were produced using hot melt extrusion. Since ITZ possesses a water solubility of less than 1ng/mL, the aim of this work was to enhance the aqueous solubility of ITZ, and thereby improve its bioavailability. The three for...

S. securidaca seeds are reported to treat a variety of diseases; they contain multiple antidiabetic constituents and widely used as anti-hyperglycemic, antibacterial, well anti-hyperlipidemic agents. The present work aimed propose tablet formulations containing extracts in an attempt obtain antibacterial anti-hyperglycemic with more efficient oral hypoglycemic impact, limited side effects, high...

The effect, of varying the proportion of binder starch paste (SP) and the disintegrant sodium starch glycolate (SSG), on the compaction behavior of wet granulated acetaminophen (ACM) formulations using a fully instrumented rotary tablet press, was studied. Wet granulation formulations were prepared using ACM, SP as binder (equal to 2.5%, 5% or 10% starch concentration), SSG as disintegrant (0%,...

trichomoniasis, the most widespread sexually transmitted disease is caused by trichomonas vaginalis. this parasite is site specific for the genitourinary tract and recruitment of macrophages as well as polymorphonuclear nutrophils (pmn) to the site of infection is the first line of defense as a component of non-specific resistance and immunity. in this study, balb/c mice were infected with 10 i...

The aim of this research was to investigate the disintegrant properties modified Cenchrus americanus starch (MCS) in chlorpheniramine maleate tablets formulation. matured seeds C. were steeped 4 L 0.25 % w/v sodium hydroxide at 5 °C for 24h, washed, soaked distilled water (30 ± 2 °C) 24 h, and wet milled. slurry washed with through a 200 mesh screen, filtrate left undisturbed 18 h. top layer se...

to investigate the effects of drought stress and different combinations of animal manure with super absorbent polymer on yield and yield components of corn, a split plots design was conducted based on a randomized complete block design with 3 replications in fars agricultural research center in 2007. irrigation treatments were assigned as the main factor in three levels: 70, 105 and 140 mm evap...