نتایج جستجو برای: superior genotype
تعداد نتایج: 233446 فیلتر نتایج به سال:
A fundamental component of brain development is the formation of large-scale networks across the cortex. One such network, the default network, undergoes a protracted development, displaying weak connectivity in childhood that strengthens in adolescence and becomes most robust in adulthood. Little is known about the genetic contributions to default network connectivity in adulthood or during de...
Tef (Eragrostis tef [Zucc.] Trotter) is a tiny-seeded cereal with huge importance in Ethiopia. Creation of variability by hybridization and the subsequent selection RILs very important towards variety development. In order to identify superior genotypes, evaluation was performed on eight environments using three times replicated randomized complete block design. The result revealed that genotyp...
Phenotype prediction from genotype data is one of the most important issues in computational genetics. In this work, we propose a new kernel (i.e., an SVM: Support Vector Machine) method for phenotype prediction from genotype data. In our method, we first infer multiple suboptimal haplotype candidates from each genotype by using the HMM (Hidden Markov Model), and the kernel matrix is computed b...
A basic principle of animal production is that individual performance is determined by genetic makeup and environmental conditions. Accordingly, individuals with above average phenotypes can result from superior genotypes, favourable environments, or both. Prior to weaning, it is the prenatal and then milking and mothering ability of the dam that provides an important component of a young anima...
Manganese (Mn) toxicity is a major constraint limiting plant growth on acidic soils. Superior Mn tolerance in Stylosanthes spp. has been well documented, but its molecular mechanisms remain largely unknown. In this study, superior Mn tolerance in Stylosanthes guianensis was confirmed, as reflected by a high Mn toxicity threshold. Furthermore, genetic variation of Mn tolerance was evaluated usin...
Abstract Integrating gene expression across tissues and cell types is crucial for understanding the coordinated biological mechanisms that drive disease characterize homoeostasis. However, traditional multi-tissue integration methods either cannot handle uncollected or rely on genotype information, which often unavailable subject to privacy concerns. Here we present HYFA (hypergraph factorizati...
Common genetic variation in the promoter region of the glutamate receptor delta 1 (GRID1) gene has recently been shown to confer increased risk for schizophrenia in several independent large samples. We analysed high-resolution magnetic resonance imaging (MRI) data from 62 patients with schizophrenia and 54 healthy controls using voxel-based morphometry (VBM) to assess the effect of single nucl...
BACKGROUND Earlier studies implicated norepinephrine transporter (NET) gene (SLC6A2) polymorphisms in the etiology of major depressive disorder (MDD). Recently, two single nucleotide SLC6A2 polymorphisms, G1287A in exon 9 and T-182C in the promoter region, were found to be associated with MDD in different populations. We investigated the relationship between the brain volume and these two polym...
BACKGROUND/AIMS We aimed to evaluate the efficacy and safety of peginterferon plus ribavirin for chronic hepatitis C (CHC) patients under real life setting in Korea. METHODS We retrospectively analyzed the medical records of 758 CHC patients treated with peginterferon plus ribavirin between 2000 and 2008 from 14 university hospitals in the Gyeonggi-Incheon area in Korea. RESULTS Hepatitis C...
The CDIPT is crucial to the fatty acid metabolic pathway, intracellular signal transduction and energy metabolism in eukaryotic cells. We detected three SNPs at 3'-untranslated regions (UTR), named 3'-UTR_108 A > G, 3'-UTR_448 G > A and 3'-UTR_477 C > G, of the CDIPT gene in 618 Qinchuan cattle using PCR-RFLP and DNA sequencing methods. At each of the three SNPs, we found three genotypes named ...
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