Alveolar macrophages and neutrophils produce superoxide and other free radicals which are important in killing bacteria. The focus of this paper is the inhibition by ethanol of superoxide production and anti-bacterial activity. The signal transduction pathways leading to superoxide production by phagocytic cells will be reviewed. Our hypothesis is that ethanol alters these signal transduction p...

This study investigated whether production of reactive oxygen species by neutrophils differs between women with preeclampsia and those with essential hypertension. First, we assessed superoxide production by neutrophils during pregnancy and 4 weeks after delivery in 15 healthy pregnant women, 12 women with preeclampsia, and 7 pregnant women with essential hypertension. We then examined effects ...

The mitochondrial cytochrome bc(1) complex (ubiquinol/cytochrome c oxidoreductase) is generally thought to generate superoxide anion that participates in cell signaling and contributes to cellular damage in aging and degenerative disease. However, the isolated, detergent-solubilized bc(1) complex does not generate measurable amounts of superoxide except when inhibited by antimycin. In addition,...

When l-arginine is depleted, neuronal nitric oxide synthase (nNOS) has been reported to generate superoxide. A flavoprotein module construct of nNOS has been demonstrated to be sufficient for superoxide production. In contrast, nNOS was reported not to be involved in superoxide formation, because such formation occurred with a mixture of the boiled enzyme and redox-active cofactors. We aimed to...

trichosanthes kirilowii, an important economic plant in china, is sensitive to chilling. to investigate the effect of abscisic acid (aba) treatment on the chilling tolerance of trichosanthes kirilowii maxim, different concentrations of aba were sprayed on trichosanthes kirilowii leaves and the resulting catalase (cat) and superoxide dismutase (sod) activities and the malondialdehyde (mda) conte...

selenium is an essential element for humans, therefore, adding it to plants is convenient for biofortification. thus, the aim of this work was to analyze experimentally the ability of sodium selenite to increase the concentration of se and modify the antioxidant activity in tomato plants. we used plants of the toro hybrid variety and applied three treatments: 0, 2 and 5 mg l-1 of selenium as so...

subclinical mastitis is considered as one of the most prevalent diseases in dairy cows, causing drasticloss in the dairy industry. oxidative stress, induced by reactive oxygen species (ros), is believed to be aprimary factor in various cattle diseases including mastitis, but there are few studies regarding the role ofros in subclinical mastitis. this study was undertaken to i) study the changes...

objective: electro-magnetic radiation (emr) is emitted from mobile phones. various researches have shown relationships between mobile phone emr exposure to cancer and neurologic damages. this study aims to investigate the effects of mobile phone emr on brain antioxidant enzyme activity and the learning process. methods: rat pups and their dames were exposed to emr for 3 h per day from p2 to p1...

diabetes mellitus (dm) is a chronic heterogeneous disorder and oxidative stress is a key participant in the development and progression of it and its complications. anti-oxidant status can affect vulnerability to oxidative damage, onset and progression of diabetes and diabetes complications. superoxide dismutase 2 (sod2) is one of the major antioxidant defense systems against free radicals. sod...