Central core disease (CCD) is an inherited neuromuscular disorder characterised by central cores on muscle biopsy and clinical features of a congenital myopathy. Prevalence is unknown but the condition is probably more common than other congenital myopathies. CCD typically presents in infancy with hypotonia and motor developmental delay and is characterized by predominantly proximal weakness pr...

INTRODUCTION Itraconazole is an anti-fungal agent widely used to treat various forms of mycosis. It is particularly useful in allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization. Side effects are uncommon and usually mild. Mild neuropathy is noted to occur very rarely. We present an unusual and, to the best of our knowledge, as yet unreported case of severe neuro...

Guillain-Barré syndrome (GBS) is a very rare immune mediated disorder which is associated with demyelination of peripheral nervous system and progressive muscle weakness that occurs mostly in previously healthy individuals. It usually presents with ascending paralysis and is severe enough to warrant hospital admission for its management. The incidence of GBS is 1.1-1.8 cases in 100,000 per year...

Dose and schedule are important factors in the therapy of cancer. Animal model and clinical data show that there is a significant correlation between dose-intensity and survival; moreover, the shortening of interval between chemotherapy cycles prevents from tumor regrowth and maximize the effect of chemotherapy on cancer cells (Gregory SA, Trumper L, 2005). Most of anti-cancer drugs are non-sel...

Presentation of botulism in adults is extremely rare and symptoms can be easily confused for acute stroke, Guillain-Barre, or myasthenia gravis. The purpose this clinical case report to ensure adult will included the differential diagnoses a patient with presentation so swift accurate care provided optimal outcome. A 41-year-old-female presented complaints sudden onset difficulty speaking. repo...

Current practice and guidelines recommend the use of neck orthoses for people with amyotrophic lateral sclerosis (ALS) to compensate for neck weakness and to provide surrogate neck control. However, available options are frequently described by patients as restrictive and unsuitable and there was a need for a new device that addressed the needs of people with ALS. This project utilized a co-des...

PATIENT Female, 75 FINAL DIAGNOSIS: Hypertensive crisis with multi organ failure Symptoms: Anemia • general weakness • hypokalemia • nausea • tachycardia MEDICATION - Clinical Procedure: - Specialty: Cardiology. OBJECTIVE Unexpected drug reaction. BACKGROUND Skin reactions are common adverse drug reactions and may include angioedema, erythroderma, Stevens-Johnson syndrome, and toxic epide...

Japanese encephalitis (JE) is an infectious encephalitis prevalent in Asia. It usually presents with fever, headache, convulsions and extrapyramidal symptoms. Limbic system involvement and hypothermia though common in autoimmune encephalitis have never been reported in JE. We report a case of an 18-year-old girl with no previous comorbidities who presented to us with a history of fever and head...