Today, the issue of studying mechanisms impact social stress on public health and its role in formation key human diseases is relevant necessary. A large number works, both clinical observations experimental studies, are devoted to this problem. However, despite high interest problem, there still "white spots". Therefore, purpose our study was analyze modern sources information that highlight c...

The ontogenetic development of the noradrenergic innervation of the supraoptic nucleus was studied in the Brattleboro rat at late postcoital and early postnatal ages. This genetic mutant offers a useful model for analysis of neuronal development because of the absence of a specific peptide component of identifiable target neurons and has been used presently to eliminate the possibility that suc...

The effects of naloxone on the release of oxytocin and vasopressin in discrete brain areas were investigated in control and morphine-tolerant/dependent female rats anesthetized with urethane. Two or three consecutive push-pull perfusates were collected for 30-40 min each and the peptide contents measured by radioimmunoassay; naloxone (5 mg/kg, i.v.) was given after the first perfusion. In contr...

Osmosensory neurons transduce osmotic signals into a neural spike code that commands behavioral and endocrine responses that mediate body fluid homeostasis. Although changes in osmoregulatory reflex gain are known to occur under physiological and pathological conditions, the basis for this modulation is unknown. Here, we show that angiotensin II amplifies osmosensory transduction by enhancing t...

Following the reports of J. L. Pines (1925) and R. Grevi ng (1926) on tractus supraoptico-hypophyseus, a nerve tract running from nucleus supraopticus to the hypophysis, the existence of tractus supraopticohypophyseus and tractus paraventricularis cinereus (tractus paraventriculohypophyseus) communicating the large cellular nuclei of the hypothalamus (i. e, nucleus supraopticus, nucleus supraop...

Tritiated leucine was intraperitoneally injected into normal and castrated female rats, and the uptake in the brain was autoradiographically studied 2hr after the injection. Radioactivity was estimated by counting the number of reduced grains in various areas of the brain. In normal animals, the highest uptake of radioisotope was found in the cell bodies of neurons in the supraoptic nucleus. A ...