CTP:phosphocholine cytidylyltransferase (CT) is the rate-limiting enzyme in the biosynthesis by type II pneumocytes of phosphatidylcholine (PC), the predominant phospholipid in lung surfactant. Augmentation of endogenous CT activity might therefore result in enhanced surfactant PC production. To test this hypothesis, transgenic mice were created in which rat CT (rCT) was expressed under control...

Objective: To Formulate and Evaluate Nanoemulsions of Caffeic acid to overcome its poor aqueous solubility bioavailability. Methods: The caffeic nanoemulsions were prepared by spontaneous emulsification method through selection oil phase based on studies surfactant co-surfactant screening the basis their ability. components selected maximum in various media such as isopropyl myristate phase, tw...

The inadequate management of wastes associated with chlorinated organic compounds (COCs) has become a huge environmental problem. Surfactant Enhanced In-Situ Chemical Oxidation (S-ISCO) was studied as successful technique to remediate polluted sites. This work investigated the reaction between an aqueous solution nonionic surfactant (Emulse-3®) and oxidant (sodium persulfate activated NaOH) rea...

The objective of this study was to investigate the influence of surfactant charge, surfactant carbon chain length, and surfactant content on the physicochemical characteristics (ie, vesicle size, zeta potential, elasticity, and entrapment efficiency), morphology, stability, and in vitro skin permeability of meloxicam (MX)-loaded liposome. Moreover, the mechanism for the liposome-enhanced skin p...

Incorporation of pulmonary surfactant into fibrin inhibits its plasmic degradation. In the present study we investigated the influence of the surfactant proteins (SP)-A, SP-B and SP-C on the fibrinolysis-inhibitory capacity of surfactant phospholipids. Plasmin-induced fibrinolysis was quantified by means of a I-fibrin plate assay and surfactant incorporation into polymerizing fibrin was analyse...

Pulmonary surfactant reduces surface tension at the lung air-liquid interface and defends the host against infection. Several lines of evidence show that surfactant levels are altered in animal models and patients with inflammatory or infectious lung diseases. We tested the hypothesis that cells responding to lung injury alter surfactant levels through increased phospholipid clearance. Acute lu...

The efficacy of antioxidant enzymes to limit oxidant lung injury by instillation with surfactant mixtures in preterm infants with hyaline membrane disease is under investigation. However, there is concern that instillation of proteins in the alveolar space may inactivate pulmonary surfactant. We studied the effects of bovine copper-zinc superoxide dismutase (CuZn-SOD) on the biophysical propert...

conclusions the findings of this study showed that the modification of natural zeolites can achieve higher adsorption capacity for organics. in addition, based on the results, natural zeolite being modified with sds as a cationic surfactant had good efficiency for the adsorption of nom. results the results indicated that sds-modified zeolite showed greatly enhanced adsorption capacity. findings...

Physico-chemical properties, molecular interactions and thermodynamic stability of human and bovine serum albumins in complexes with mitomycin C were investigated. The pH and temperature influence on serum albumins properties and the binding mechanism of mitomycin C to these proteins have been monitored by spectrometry and spectrofluorimetry methods.

A simple identification method of L-tyrosine (Tyr) and L-cysteine (Cys) using gemini surfactant coated CdSe quantum dots by using a fluorescent spectroscopic technique is proposed. The gemini surfactant modified QDs show a selective fluorescence response between Tyr and Cys by addition of p-sulfonatocalix[4]arene (pSCA). The CdSe QDs coated with gemini surfactant [C(12)H(25)N(+)(CH(3))(2)(CH(2)...