BACKGROUND Intraoperative cell salvage exerts shear stress upon RBCs, particularly as they are suctioned from the surgical field. Shear stress can result in overt hemolysis or it can cause sublethal injury to the suctioned RBCs. The mechanical fragility (MF) test uses shear stress to measure the extent of RBC sublethal injury. RBCs that have sustained sublethal injury are more susceptible to sh...

BACKGROUND The intestine is increasingly recognized as a primary effector of distant organ damage, such as lung, following abdominal surgery. Surgical manipulation of the intestine generates oxygen free radicals resulting in mucosal damage. Heat preconditioning has been proposed to prevent various stress-induced alterations in cells and tissues, including oxidative stress. This study examined t...

Medial collateral ligament tears usually will be treated through non-surgical methods, but, in some cases such as thosewith tears at the distal insertion where the reduction could be blocked by the pes anserine tendons (Stener-like lesion), surgerywill be performed. Here, we present a surgical technique in such cases. In this retrospective case series, we describesix patients diagnosed with Ste...

Anti-tumor CD8+ T cells are a key determinant for overall survival in patients following surgical resection for solid malignancies. Using a mouse model of cancer vaccination (adenovirus expressing melanoma tumor-associated antigen (TAA)-dopachrome tautomerase (AdDCT) and resection resulting in major surgical stress (abdominal nephrectomy), we demonstrate that surgical stress results in a reduct...

The endocrine, metabolic and inflammatory responses to injury and infection are composed of a variety of physiological changes often grouped together and called the surgical stress response. Over the past few decades, detailed knowledge has accumulated on this response and has allowed consideration and development of therapeutic manoeuvres designed to assist or manipulate the patient's response...

Surgical stress responses cause an array of endocrinological, metabolic and immunological changes in patients. The landmark studies in the 1980s showed that adequate anesthesia dramatically improved the outcomes of pediatric surgical patients by attenuating stress hormonal responses, pointing out the harm of 'inadequate' anesthesia. Subsequent studies questioned the role of administering very h...

Lateral ray stress fractures are a known complication of the cavovarus foot deformity. Malpositioning of the forefoot and hindfoot leads to increased pressure on the heel and lateral rays, resulting in significant morbidity. Patients with nonprogressive deformities can be managed surgically or nonsurgically in an attempt to decrease adverse events. It is often difficult to predict which patient...

Aim To evaluate whether performing ventral hernia repairs using the Ethicon Physiomesh™ Open Flexible Composite Mesh Device in conjunction with the Ethicon Securestrap® Open Absorbable Strap Fixation Device reduces surgical time and surgeon stress levels, compared with traditional surgical repair methods. Methods To repair a simulated ventral incisional hernia, two surgeries were performed by...

Background: This study aimed to investigate the status and correlation between occupational stress and sleep quality of the nurses working in the cardiac surgical Intensive Care Unit (ICU). Methods: Sixty cardiac surgical ICU nurses from two central hospitals in Shanghai were investigated by a general information questionnaire and the Occupational Stress Inventory Revised Edition OSI-R (OSI-R) ...